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首页> 外文期刊>Alcohol >Predictors of ethanol consumption in adult Sprague-Dawley rats: relation to hypothalamic peptides that stimulate ethanol intake.
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Predictors of ethanol consumption in adult Sprague-Dawley rats: relation to hypothalamic peptides that stimulate ethanol intake.

机译：成年Sprague-Dawley大鼠的乙醇消耗预测因素：与刺激乙醇摄入的下丘脑肽有关。

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To investigate mechanisms in outbred animals that increase the propensity to consume ethanol, it is important to identify and characterize these animals before or at early stages in their exposure to ethanol. In the present study, different measures were examined in adult Sprague-Dawley rats to determine whether they can predict long-term propensity to overconsume ethanol. Before consuming 9% ethanol with a two-bottle choice paradigm, rats were examined with the commonly used behavioral measures of novelty-induced locomotor activity and anxiety, as assessed during 15 min in an open-field activity chamber. Two additional measures, intake of a low 2% ethanol concentration or circulating triglyceride (TG) levels after a meal, were also examined with respect to their ability to predict chronic 9% ethanol consumption. The results revealed significant positive correlations across individual rats between the amount of 9% ethanol ultimately consumed and three of these different measures, with high scores for activity, 2% ethanol intake, and TGs identifying rats that consume 150% more ethanol than rats with low scores. Measurements of hypothalamic peptides that stimulate ethanol intake suggest that they contribute early to the greater ethanol consumption predicted by these high scores. Rats with high 2% ethanol intake or high TGs, two measures found to be closely related, had significantly elevated expression of enkephalin (ENK) and galanin (GAL) in the hypothalamic paraventricular nucleus (PVN) but no change in neuropeptide Y (NPY) in the arcuate nucleus (ARC). This is in contrast to rats with high activity scores, which in addition to elevated PVN ENK expression showed enhanced NPY in the ARC but no change in GAL. Elevated ENK is a common characteristic related to all three predictors of chronic ethanol intake, whereas the other peptides differentiate these predictors, with GAL enhanced with high 2% ethanol intake and TG measures but NPY related to activity.
机译：为了研究近亲动物增加乙醇消费倾向的机制，重要的是在这些动物接触乙醇之前或早期对其进行鉴定和表征。在本研究中，对成年Sprague-Dawley大鼠进行了不同的测定，以确定它们是否可以预测长期过量摄入乙醇的倾向。在以两瓶选择范式消费9％的乙醇之前，先对大鼠进行了新颖的运动活动和焦虑的常用行为量度检查，如在露天活动室中进行了15分钟的评估。还针对其预测慢性9％乙醇消耗的能力，检查了另外两种测量方法，即摄入低2％乙醇浓度或餐后循环甘油三酯（TG）的水平。结果显示，在个别大鼠中，最终消耗的9％乙醇的量与其中三种不同的度量之间存在显着的正相关性，其中活动得分高，乙醇摄入量为2％且TG的得分高，而酒精消耗低的大鼠要多消耗150％分数。对刺激乙醇摄入的下丘脑肽的测量表明，它们在这些高分所预测的乙醇消耗量增加中起了早期作用。发现有2％的乙醇摄入量高或TGs高的大鼠具有密切相关性，在下丘脑室旁核（PVN）中脑啡肽（ENK）和甘丙肽（GAL）的表达明显升高，但神经肽Y（NPY）没有变化在弓形核（ARC）中。这与具有高活动评分的大鼠相反，该活动评分除了PVN ENK表达升高外，在ARC中还显示出NPY增强，但GAL没有变化。升高的ENK是与慢性乙醇摄入的所有三个预测因子有关的共同特征，而其他肽则区分了这些预测因子，GAL的摄入量高于2％的乙醇摄入量和TG值可以增强GAL，而NPY与活性有关。

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