...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Alcohol >Breast pumping and lactational state exert differential effects on ethanol pharmacokinetics.
【24h】

Breast pumping and lactational state exert differential effects on ethanol pharmacokinetics.

机译：吸乳和哺乳状态对乙醇的药代动力学有不同的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prior research revealed that breast stimulation altered the way the lactating body handles alcohol. Its effects depended upon when it occurred relative to drinking. The goal of the present study was to determine whether breast pumping works independently of the physiological and metabolic changes that accompany lactation. To this end, we tested 12 women when they were exclusively breastfeeding 3-5-month-old infants and then again several months after lactation had ceased. Subjects were randomly assigned to one of two groups that differed in the timing of breast pumping relative to drinking a 0.4g/kg dose of alcohol: one group breast pumped 0.6h after drinking (pumped after group) and the other pumped 1h before drinking (pumped before group). For each reproductive stage, subjects were tested on 2 separate days, consuming a standardized meal 1 h before drinking during 1 test day and remaining fasted during the other. Breath alcohol concentrations (BrAC) and temperature readings were obtained before and at fixed intervals after drinking. Pumping before drinking significantly decreased BrAC during both reproductive stages, whereas pumping after drinking resulted in different BrAC time curves during lactation when compared with after lactation. That is, levels were significantly lower during the descending phase of the time curve during than after lactation. The interactions between pumping and reproductive stage were most apparent during fed condition. Furthermore, women were more sensitive to hypothermic effects of both fasting and drinking alcohol during lactation. These findings add to the growing literature that lactating women metabolize alcohol differently, in part, due to the frequent breast stimulation during breastfeeding and the pronounced physiological changes that accompany one of the most energetically costly mammalian activities.
机译：先前的研究表明，乳房刺激会改变泌乳体处理酒精的方式。它的作用取决于与饮酒有关的发生时间。本研究的目的是确定吸乳是否独立于哺乳期的生理和代谢变化而起作用。为此，我们对12名妇女进行纯母乳喂养的3-5个月大婴儿，然后在停止哺乳几个月后再次进行了测试。受试者被随机分为两组，两组的抽乳时间相对于饮入0.4g / kg酒精的时间有所不同：一组在饮酒后0.6h抽乳（组后抽），另一组在饮酒前1h抽乳（组前抽）。对于每个生殖阶段，受试者分别在2天中接受测试，在1个测试日中饮酒前1小时先饮用标准餐，然后在另一个测试日中禁食。饮酒前和饮酒后固定时间获得呼吸酒精浓度（BrAC）和温度读数。饮酒前的抽水在两个生殖阶段均显着降低了BrAC，而饮酒后的抽水与哺乳后相比，在哺乳期产生了不同的BrAC时间曲线。也就是说，在时间曲线的下降阶段，其水平显着低于泌乳后的水平。在进食条件下，抽水与生殖阶段之间的相互作用最为明显。此外，女性对哺乳期间禁食和饮酒的体温过低影响更为敏感。这些发现增加了越来越多的文献，哺乳期妇女不同地代谢酒精，部分原因是母乳喂养期间频繁的乳房刺激以及伴随着能量消耗最大的哺乳动物活动之一的明显的生理变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号