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首页> 外文期刊>Alcohol >Altered anxiety-like behavior and long-term potentiation in the bed nucleus of the stria terminalis in adult mice exposed to chronic social isolation, unpredictable stress, and ethanol beginning in adolescence
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Altered anxiety-like behavior and long-term potentiation in the bed nucleus of the stria terminalis in adult mice exposed to chronic social isolation, unpredictable stress, and ethanol beginning in adolescence

机译：暴露于慢性社会隔离，不可预测的压力和青春期开始的成年小鼠的成年小鼠纹状体终末床核中焦虑样行为和长期增强的改变

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Alcohol and chronic stress exposure, especially during adolescence, can lead to an increased risk in adulthood of developing alcohol use disorders. To date, however, no study has assessed the potential long-term effects of chronic intermittent and unpredictable ethanol (EtOH) exposure in mice chronically stressed beginning in adolescence on brain function and anxiety-like behaviors in adulthood. In particular, alterations in function of the bed nucleus of the stria terminalis (BNST), a brain region heavily implicated in anxiety-related behaviors and altered plasticity following EtOH exposure, may play a key role in the pathological responses to chronic stress and EtOH. In the present study, adolescent and adult C57Bl/6J mice were exposed to a regimen of chronic social isolation and unpredictable stressors and EtOH (or air [sham]; CSI-CUS-EtOH and CSI-CUS-Sham, respectively) for 8-10 weeks. In adulthood, mice were tested for altered anxiety-like behavior (elevated plus maze [EPM] and modified social interaction [SI] test). Following behavioral testing, mice were reexposed to CSI-CUS-EtOH (and CSI-CUS-Sham for controls) for an additional 3 days. Four to six hours following the final EtOH (or air) exposure, field potential recordings of the dorsal-lateral (dl)BNST were performed. Mice first exposed during adolescence to CSI-CUS-EtOH displayed lower levels of anxiety-like behavior on the EPM compared with mice first exposed to CSI-CUS-EtOH during adulthood and control mice only exposed to CSI-CUS-Sham, regardless of age of first exposure. However, mice first exposed to CSI-CUS-EtOH during adulthood displayed lower levels of anxiety-like behavior on the SI test compared with mice first exposed during adolescence and control CSI-CUS-Sham mice. CSI-CUS-EtOH exposure, regardless of age, produced blunted expression of long-term potentiation (LTP) in the dlBNST compared with CSI-CUS-Sham mice. This study demonstrates age-dependent effects of chronic unpredictable ethanol exposure in chronically stressed mice on anxiety-like behaviors during adulthood. Further, CSI-CUS-EtOH exposure results in blunted LTP expression in the adult dlBNST.
机译：酒精和慢性应激暴露，尤其是在青春期，可能导致成年后发展为酒精使用障碍的风险增加。然而，迄今为止，尚无研究评估长期间歇性和不可预测的乙醇（EtOH）暴露对从青春期开始长期处于应激状态的成年小鼠大脑功能和焦虑样行为的潜在长期影响。特别是，暴露于EtOH后，与焦虑相关行为和可塑性改变密切相关的大脑区域终末皮层（BNST）床核功能的改变，可能在对慢性应激和EtOH的病理反应中起关键作用。在本研究中，青少年C57Bl / 6J和成年C57Bl / 6J小鼠接受了长期的社会隔离和不可预测的压力和EtOH（或空气[sham]; CSI-CUS-EtOH和CSI-CUS-Sham）方案，治疗8天10个星期。成年后，测试小鼠的焦虑样行为改变（高迷宫[EPM]和改良的社交互动[SI]测试）。进行行为测试后，将小鼠再暴露于CSI-CUS-EtOH（和CSI-CUS-Sham作为对照）中再暴露3天。在最终的EtOH（或空气）暴露后四到六小时，进行背侧（dl）BNST的场电势记录。与成年期首次暴露于CSI-CUS-EtOH的小鼠相比，青春期期间首次暴露于CSI-CUS-EtOH的小鼠表现出更低的焦虑样行为水平，而无论年龄大小，对照小鼠仅暴露于CSI-CUS-EtOH的第一次曝光。但是，与在青春期和对照组CSI-CUS-Sham小鼠中首次接触的小鼠相比，在成年期间首次接触CSI-CUS-EtOH的小鼠表现出较低的焦虑样行为水平。与CSI-CUS-Sham小鼠相比，无论年龄大小，CSI-CUS-EtOH暴露在dlBNST中都会产生钝化的长期增强（LTP）表达。这项研究证明了慢性应激的小鼠长期无法预测的乙醇暴露对成年期焦虑样行为的年龄依赖性影响。此外，CSI-CUS-EtOH暴露导致成年dlBNST中的LTP表达减弱。

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