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首页> 外文期刊>Alcohol >The comparative effects of clozapine versus haloperidol on initiation and maintenance of alcohol drinking in male alcohol-preferring P rat
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The comparative effects of clozapine versus haloperidol on initiation and maintenance of alcohol drinking in male alcohol-preferring P rat

机译：氯氮平与氟哌啶醇对雄性偏爱酒精的P大鼠开始饮酒和维持饮酒的比较作用

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Alcohol use disorder, characterized by modest levels of alcohol use, commonly occurs in patients with schizophrenia and dramatically worsens their course. Recent data indicate that the atypical antipsychotic clozapine, but not the typical antipsychotic haloperidol, decreases alcohol drinking both in patients with schizophrenia and also in the Syrian golden hamster, an animal model of moderate alcohol drinking. The present study was designed to assess the comparative effects of clozapine and haloperidol in the alcohol-preferring (P) rat, an animal model of alcoholism. First, the study investigated the comparative effects of clozapine and haloperidol on initiation of alcohol consumption in P rats, which models the early stage of alcoholism. Second, the study assessed the comparative effects of clozapine and haloperidol on maintenance of chronic alcohol consumption in P rats to provide a clue as to whether either drug may also limit alcohol consumption in alcohol-dependent patients. Clozapine attenuated the initiation of alcohol drinking and development of alcohol preference while haloperidol did not. However, neither clozapine nor haloperidol attenuated maintenance of chronic alcohol drinking. Taken together, the current data suggest that clozapine, but not haloperidol, may be effective at reducing alcohol abuse or non-dependent drinking and the P rat, used within an alcohol initiation paradigm, and may differentiate the effects of clozapine and haloperidol on alcohol drinking.
机译：以适度饮酒为特征的饮酒障碍通常在精神分裂症患者中发生，并严重恶化其病程。最新数据表明，非典型的抗精神病药物氯氮平，而不是典型的抗精神病药物氟哌啶醇，在精神分裂症患者和叙利亚中的金仓鼠（一种适度饮酒的动物模型）中均可降低饮酒量。本研究旨在评估氯氮平和氟哌啶醇在酒精中毒动物模型（偏爱酒精的大鼠）中的比较作用。首先，该研究调查了氯氮平和氟哌啶醇对P鼠饮酒开始的比较作用，该模型模拟了酒精中毒的早期阶段。其次，该研究评估了氯氮平和氟哌啶醇对维持P大鼠慢性饮酒的比较作用，以提供关于这两种药物是否也可能限制酒精依赖患者饮酒的线索。氯氮平减弱了饮酒的开始和酒精偏好的发展，而氟哌啶醇没有。但是，氯氮平和氟哌啶醇均不能减弱长期饮酒的维持率。综上所述，目前的数据表明，氯氮平而不是氟哌啶醇可以有效减少酒精滥用或非依赖性饮酒，而在酒精引发范例中使用的P大鼠可以区分氯氮平和氟哌啶醇对饮酒的影响。

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