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Associations between heavy alcohol drinking and lipid-related indices in middle-aged men

机译：中年男子酗酒与血脂相关指数之间的关系

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The ratio of triglycerides to HDL cholesterol (TG/HDL-C ratio) and lipid accumulation product (LAP: a continuous marker of lipid over-accumulation determined by waist circumference and triglycerides) have been proposed to be good predictors of cardiovascular disease. The aim of this study was to clarify the relationships between heavy alcohol drinking and lipid-related indices including TG/HDL-C ratio, LAP, and ratio of LDL cholesterol to HDL cholesterol (LDL-C/HDL-C ratio). The subjects were middle-aged male nondrinkers and heavy drinkers (ethanol intake: ≥66g per drinking day, which is 2-3 times or more than the generally recommended border level of daily alcohol consumption of 20-30g). The levels of each lipid-related index after adjustment for age, smoking, and regular exercise were compared among nondrinkers, occasional heavy drinkers, and regular heavy drinkers. Log-transformed TG/HDL-C ratio was significantly higher in occasional heavy drinkers (mean±standard error: 0.445±0.014) than in nondrinkers (0.388±0.004) and regular heavy drinkers (0.359±0.013), and was not significantly different in nondrinkers and regular heavy drinkers. Log-transformed LAP was significantly higher in occasional heavy drinkers (1.51±0.02) and regular heavy drinkers (1.44±0.02) than in nondrinkers (1.34±0.01), and was significantly higher in occasional heavy drinkers than in regular heavy drinkers. LDL-C/HDL-C ratio was significantly lower in occasional heavy drinkers (2.41±0.04) and regular heavy drinkers (1.72±0.04) than in nondrinkers (2.62±0.01) and was significantly lower in regular heavy drinkers than in occasional heavy drinkers. Results of logistic regression analysis, using odds ratios for high lipid indices of occasional or regular heavy drinkers vs. nondrinkers, agreed with the above results of analysis of covariance. Occasional heavy drinkers showed more detrimental and less favorable levels of the lipid indices than did regular heavy drinkers, and thus heavy drinking, even if occasional, should be avoided to prevent cardiovascular disease.
机译：甘油三酸酯与HDL胆固醇的比例（TG / HDL-C比例）和脂质积聚产物（LAP：由腰围和甘油三酸酯确定的脂质过度积聚的连续标志）已被认为是心血管疾病的良好预测指标。这项研究的目的是弄清重度饮酒与脂质相关指标之间的关系，包括TG / HDL-C比，LAP以及LDL胆固醇与HDL胆固醇的比（LDL-C / HDL-C比）。受试者为中年男性不饮酒者和重度饮酒者（乙醇摄入量：每天饮酒≥66g，是一般建议的每日饮酒量20-30g的边界水平的2-3倍或更多）。比较了不饮酒者，偶尔重度饮酒者和定期重度饮酒者的年龄，吸烟和经常运动后的每个脂质相关指数的水平。对数转换后的TG / HDL-C比率在偶尔重度饮酒者（平均值±标准误差：0.445±0.014）中显着高于非饮酒者（0.388±0.004）和常规重度饮酒者（0.359±0.013），在非饮酒者和经常饮酒的人。对数转化的LAP在偶尔重度饮酒者（1.51±0.02）和常规重度饮酒者（1.44±0.02）中显着高于非饮酒者（1.34±0.01），在偶然重度饮酒者中显着高于常规重度饮酒者。 LDL-C / HDL-C比重度饮酒者（2.41±0.04）和常规重度饮酒者（1.72±0.04）显着低于非重度饮酒者（2.62±0.01），而常规重度饮酒者的LDL-C / HDL-C比显着降低。 Logistic回归分析的结果使用偶然或经常大量饮酒者与非饮酒者与非饮酒者的高脂质指数的比值比，与上述协方差分析结果一致。与常规的重度饮酒者相比，偶尔的重度饮酒者显示出更大的有害性和不利的脂质指数水平，因此即使避免偶尔饮酒也应避免预防心血管疾病。

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