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首页> 外文期刊>Alcohol >Selective breeding for ethanol-related traits alters circadian phenotype.
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Selective breeding for ethanol-related traits alters circadian phenotype.

机译：乙醇相关性状的选择性育种改变了生物钟表型。

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Previous studies in mice and rats have shown that selective breeding for high and low ethanol preference results in divergence of circadian phenotype in the selected lines. These results indicate that some alleles influencing ethanol preference also contribute to circadian rhythm regulation. Selective breeding has also been used to produce lines of mice differing in a number of other ethanol-related traits, while studies of phenotypic and genetic correlation indicate that diverse ethanol-related traits are influenced by both shared and unshared genetics. In the present study, we examined several features of circadian activity rhythms in a mouse line selected for binge-like drinking and in mouse lines selected for high and low severity of ethanol withdrawal convulsions. Specifically, Experiment 1 compared High Drinking in the Dark (HDID-1) mice to their genetically heterogeneous progenitor line (HS/Npt), and Experiment 2 compared Withdrawal Seizure-Prone (WSP-2) and Withdrawal Seizure-Resistant (WSR-2) mice. Both line pairs displayed differences in their daily activity patterns under light-dark conditions. In addition, HDID-1 mice showed shorter free-running periods in constant light and less coherent activity rhythms across lighting conditions relative to HS/Npt controls, while WSP-2 mice showed longer free-running periods in constant darkness relative to WSR-2 mice. These results strengthen the evidence for genetic linkages between responsiveness to ethanol and circadian regulation, and extend this evidence to include ethanol-related phenotypes other than preference drinking. However, the present results also indicate that the nature of genetic correlations between and within phenotypic domains is highly complex.
机译：先前在小鼠和大鼠中的研究表明，针对高乙醇偏爱和低乙醇偏爱的选择性育种会导致所选品系的生物钟表型出现差异。这些结果表明，一些影响乙醇偏好的等位基因也有助于昼夜节律的调节。选择性育种也已用于生产在许多其他与乙醇相关的性状上不同的小鼠品系，而对表型和遗传相关性的研究表明，与乙醇相关的各种性状都受到共有和不共有遗传学的影响。在本研究中，我们检查了选择用于暴饮暴食的小鼠品系和选择高低乙醇抽搐的严重程度的小鼠品系的昼夜活动节律的几个特征。具体而言，实验1比较了在黑暗中高饮（HDID-1）小鼠与其遗传异质祖细胞系（HS / Npt）的关系，实验2比较了戒断癫痫发作（WSP-2）和抗抽搐发作的耐受性（WSR-2） ） 老鼠。两条线对在明暗条件下的日常活动模式均显示出差异。此外，相对于HS / Npt对照，HDID-1小鼠在恒定光照下表现出较短的自由运行时间，并且在光照条件下相对于HS / Npt对照表现出较少的连贯活动节奏，而WSP-2小鼠在恒定黑暗条件下表现出相对于WSR-2较长的自由运行时间老鼠。这些结果加强了对乙醇反应性与昼夜节律调节之间遗传联系的证据，并将这一证据扩展到包括与酒精有关的表型，而不是偏好饮酒。但是，目前的结果还表明，表型域之间和之内的遗传相关性的性质非常复杂。

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