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首页> 外文期刊>Dermatitis: contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group >Effectiveness of Dupilumab for the Treatment of Generalized Prurigo Nodularis Phenotype of Adult Atopic Dermatitis
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Effectiveness of Dupilumab for the Treatment of Generalized Prurigo Nodularis Phenotype of Adult Atopic Dermatitis

机译：杜帕里姆人对成年人特性皮炎普遍化表型治疗的效果

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Background Generalized prurigo nodularis (GPN) is a debilitating, inflammatory skin disease characterized by chronic pruritus, signs of prolonged scratching, and multiple pruriginous papules and nodules. Recent studies identified several forms of GPN as a clinical phenotype of adult atopic dermatitis (AD). Objective The aim of the study was to evaluate the effectiveness of dupilumab (D) in adults affected by persistent AD showing a clinical feature of GPN. Methods A retrospective study was performed on adult patients affected with GPN clinical variant of AD, treated with D from July 2018 to March 2019. Atopic dermatitis severity was evaluated using the Eczema Area and Severity Index, visual analog scales ranging from 0 to 10 for pruritus, and Dermatology Life Quality Index. Results Ninety AD patients (52 males [57.7%]; mean age = 44.6 years; range = 18-66 years) were treated with D. In 9 (10.0%) of 90 cases, GPN pattern was observed. A significant improvement in Eczema Area and Severity Index, Dermatology Life Quality Index, and pruritus visual analog scale score was observed after treatment with D. Conclusions Generalized prurigo nodularis is currently considered to be a rather common clinical pattern of adult AD. Dupilumab can be an efficacious treatment of this condition, especially in cases where history of atopy is recorded and conventional treatments are ineffective.
机译：背景技术广义普里氏菌Nodularis（GPN）是一种衰弱，炎症性皮肤病，其特征在于慢性瘙痒，延长划伤的迹象和多种孕冠和结节。最近的研究确定了几种形式的GPN作为成人特应性皮炎（AD）的临床表型。目的该研究的目的是评估杜帕里姆（D）在受持续广告影响的成年人中的有效性，显示GPN的临床特征。方法对妊娠区域和严重程度指数评估了与2018年7月至2019年3月的DA治疗的AD的GPN临床变异影响的成人患者对成年患者进行了回顾性研究。使用湿疹地区和严重程度指数评估了特应性皮炎严重程度，视觉模拟尺度为瘙痒症0至10的视觉模拟尺度和皮肤科生活质量指数。结果九十令患者（52名男性[57.7％];平均年龄= 44.6岁;范围= 18-66岁）与D. 90例（10.0％）90例，观察到GPN图案。在用D治疗后观察到湿疹地区和严重程度指数，皮肤科生活质量指数和瘙痒视觉模拟比分的显着改善。目前认为广义普里氏菌Nodularis是成年广告的相当常见的临床模式。 Dupilumab可以是对这种情况的有效处理，特别是在记录特性历史的情况下并且常规治疗无效。

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