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首页> 外文期刊>Hormone research in p?diatrics >Height at start, first-year growth response and cause of shortness at birth are major determinants of adult height outcomes of short children born small for gestational age and Silver-Russell syndrome treated with growth hormone: Analysis of data from KIGS
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Height at start, first-year growth response and cause of shortness at birth are major determinants of adult height outcomes of short children born small for gestational age and Silver-Russell syndrome treated with growth hormone: Analysis of data from KIGS

机译：开始时的高度，发育的一年增长和缺点的原因是出生于妊娠期孕龄和银罗素综合征的短童成人高度成果的主要决定因素，并用生长激素治疗：分析卡格斯数据

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Background/Aims: There is limited information about adult height (AH) outcomes and the factors influencing outcomes of growth hormone (GH) therapy in short children born small for gestational age (SGA). Methods: AH (SDS) and Δheight (SDS) from GH start to AH were analyzed in 161 SGA children who had reached AH (55 with Silver-Russell syndrome, SRS). Results: SGA patients treated to AH were started on GH (median) 0.25 mg/kg/week at an age of 7.8 years with a height of -3.8 SDS. AH after 7.7 years was -2.2 SDS and -1.1 SDS below mid-parental height (MPH). AH (SDS) was explained by: height (SDS) at GH start (+), Δheight (SDS) 1st year on GH (+), years on GH (+), maternal height (SDS) (+), length (SDS) at birth (+), and the diagnosis of SRS (-) (explained variability 70%; error 0.6 SD). Gain in height (SDS) was explained by: Δheight (SDS) 1st year on GH (+), years on GH (+), height - MPH (SDS) at GH start (-) (explained variability 60%; error 0.7 SD). Conclusions: Algorithms for AH outcomes provides useful information about the potential of long-term growth on GH in short children born SGA.
机译：背景/宗旨：有关成人高度的信息有限（AH）结果以及影响胎儿胎龄出生的短童生长激素（GH）治疗的因素的因素（SGA）。方法：AH（SDS）和GH的ΔHeight（SDS）在达到AH的161名SGA儿童中分析了αH（55人，SRELS综合征，SRS）。结果：在GH（中位数）的SGA患者均在GH（中位数）0.25mg / kg /周，每年7.8岁，高度为-3.8 sds。啊7.7岁以下是-2.2 SDS和-1.1 SDS以下中期高度（MPH）。 AH（SDS）解释：GH启动（+），ΔHeight（SDS）第1年在GH（+），GH（+）多年，母体高度（SDS），长度（SDS ）在出生时（+），以及SRS（ - ）的诊断（解释可变性70％;错误0.6 SD）。高度的增益（SDS）解释：ΔHeight（SDS）第1年在GH（+），GH（+）的年份，GH启动（ - ）的高度 - MPH（SDS）（解释可变性60％;错误0.7 SD ）。结论：AH结果的算法提供了关于SGA的短童GH在GH的长期增长的潜力的有用信息。

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