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首页> 外文期刊>Alcohol >Prenatal ethanol exposure impairs spatial cognition and synaptic plasticity in female rats
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Prenatal ethanol exposure impairs spatial cognition and synaptic plasticity in female rats

机译：产前乙醇暴露会损害雌性大鼠的空间认知和突触可塑性

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Chronic prenatal ethanol exposure (CPEE) can impair long-term potentiation (LTP) in the male hippocampus. Sexually specific alterations were frequently reported in female animals that had been prenatally exposed to ethanol. This study aimed to examine the effects of CPEE on spatial learning and memory, as well as on hippocampal synaptic plasticity in female adolescent rats. Female offspring were selected from dams that had been exposed to 4 g/kg/day of ethanol throughout the gestational period. Subsequently, performance in the Morris water maze (MWM) was determined, while LTP and depotentiation were measured in the hippocampal CA3-CA1 pathway. In the behavioral test, the escape latencies in both initial and reversal training stages were significantly prolonged. Interestingly, LTP was considerably enhanced while depotentiation was significantly depressed. Our results suggest a critical role of synaptic plasticity balance, which may prominently contribute to the cognitive deficits present in CPEE offspring. (C) 2015 Elsevier Inc. All rights reserved.
机译：慢性产前乙醇暴露（CPEE）可能会损害雄性海马的长期增强（LTP）。在产前暴露于乙醇的雌性动物中，经常有性别特异性改变的报道。这项研究旨在检查CPEE对雌性青春期大鼠空间学习和记忆以及海马突触可塑性的影响。雌性后代是从在整个妊娠期都暴露于4 g / kg /天乙醇的水坝中选出的。随后，确定在莫里斯水迷宫（MWM）中的性能，同时在海马CA3-CA1途径中测量LTP和去势。在行为测试中，初始和反向训练阶段的逃生潜伏期均显着延长。有趣的是，LTP显着增强，而去势能力显着降低。我们的结果表明突触可塑性平衡的关键作用，这可能是CPEE后代中存在的认知缺陷的重要原因。 （C）2015 Elsevier Inc.保留所有权利。

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