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Locomotor and pyretic effects of MDMA-ethanol associations in rats.

机译：MDMA-乙醇缔合的运动和热效应在大鼠中。

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摘要

3,4-Methylenedioxymethamphetamine [(MDMA) or ecstasy] is a popular club drug often used in combination with ethanol. In the current study, we investigated the effects of MDMA and ethanol combinations on locomotor activity and body temperature of rats. For four consecutive days, male Long-Evans rats were treated daily with a 10-mg/kg dose of MDMA with or without a 1.5-g/kg dose of ethanol. 3,4-Methylenedioxymethamphetamine increased spontaneous activity (on average +1,140%), and this increase was potentiated by ethanol on all days (on average +1,710%). Moreover, ethanol inhibited the MDMA-induced hyperthermia (on average -1.3 degrees C) by the first day of treatment, but not on subsequent treatment days, supporting the suggestion that this effect may undergo tolerance. These observations seem to indicate that combined ethanol-MDMA may induce effects on locomotor activity and thermoregulation that involve separate mechanisms, the first one being less sensitive to tolerance than the second one might be. Results of our study have important implications for understanding the motivation and the health risks of polydrug abusers combining ecstasy and ethanol.
机译：3,4-亚甲基二氧基甲基苯丙胺[（MDMA）或摇头丸]是一种流行的俱乐部药品，通常与乙醇结合使用。在当前的研究中，我们调查了摇头丸和乙醇组合对大鼠运动能力和体温的影响。连续四天，每天对雄性Long-Evans大鼠用10-mg / kg的MDMA进行处理，有或无1.5-g / kg的乙醇。 3,4-亚甲二氧基甲基苯丙胺增加了自发活性（平均+ 1,140％），并且这种增加在整天都被乙醇增强（平均+ 1,710％）。此外，在治疗的第一天，乙醇抑制了MDMA诱导的体温过高（平均-1.3摄氏度），但在随后的治疗天中没有抑制，支持了这种作用可能会耐受的暗示。这些观察结果似乎表明，乙醇-MDMA联合使用可能诱导运动活动和体温调节的影响，涉及单独的机制，第一个对耐受性的敏感性低于第二个对耐受性的敏感性。我们的研究结果对理解迷魂药和乙醇相结合的多药滥用者的动机和健康风险具有重要意义。

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