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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Physical exercise down-regulated locomotor side effects induced by haloperidol treatment in Wistar rats.
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Physical exercise down-regulated locomotor side effects induced by haloperidol treatment in Wistar rats.

机译：体育锻炼下调了氟哌啶醇治疗对Wistar大鼠的运动副作用。

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摘要

Extra-pyramidal symptoms (EPS) such as akinesia, dystonia, gait alteration and tremors are observed when dopamine D2-receptors are blocked by pharmacological agents such as haloperidol. These alterations produce a Parkinson disease-like state (PLS). Physical exercise has been proven to improve gait and locomotor symptoms in Parkinson's disease; we sought to elucidate the effects of physical exercise on PLS induced by chronic administration of haloperidol in rats. We used 48 rats distributed into four groups: Control, Exercise, Haloperidol, and Hal+Exe. All the animals received a daily injection of saline or haloperidol for 30 days, and the exercise groups underwent a daily 30-minute exercise protocol for 20 days. The animals were subjected to the ink-paw test, bar test and open-field test throughout the training period. The haloperidol-induced akinesia increased throughout the days of injections, but exercise was shown to alleviate it. The assessment showed shortened stride length and increased stance width with the use of haloperidol, which were significantly alleviated by exercise. These results indicate that exercise could be an interesting approach towards reducing unwanted EPS caused by haloperidol.
机译：当多巴胺D2受体被氟哌啶醇等药物阻断时，会观察到锥体束外症状（EPS），如运动障碍，肌张力障碍，步态改变和震颤。这些改变产生帕金森病样状态（PLS）。事实证明，体育锻炼可以改善帕金森氏病的步态和运动症状。我们试图阐明体育锻炼对氟哌啶醇的慢性给药所致大鼠PLS的影响。我们使用了48只大鼠，分为四组：对照组，运动组，氟哌啶醇和Hal + Exe。所有动物每天接受盐水或氟哌啶醇注射30天，运动组每天进行30分钟的运动，持续20天。在整个训练期间，对动物进行墨爪测试，棒测试和野外测试。氟哌啶醇诱导的运动障碍在整个注射日中都增加，但是运动可以缓解这种情况。评估显示，使用氟哌啶醇可缩短步幅，而站姿宽度则可通过运动得到明显缓解。这些结果表明，运动可能是减少氟哌啶醇引起的不良EPS的有趣方法。

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