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首页> 外文期刊>Alcohol >Effects of ethanol consumption on vasopressin and neuropeptide Y immunoreactivity and mRNA expression in peripheral and central areas related to cardiovascular regulation.
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Effects of ethanol consumption on vasopressin and neuropeptide Y immunoreactivity and mRNA expression in peripheral and central areas related to cardiovascular regulation.

机译：饮酒对与心血管调节有关的外周和中枢血管加压素和神经肽Y免疫反应性及mRNA表达的影响。

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Results from previous studies have demonstrated that ethanol influences central neural mechanisms involved in the control of blood pressure. We studied the effects of ethanol consumption on vasopressin and neuropeptide Y immunoreactivity and mRNA expression in the nucleus tractus solitarius and paraventricular hypothalamic nucleus, as well as in the petrosal and nodose ganglia of rats. The ethanol-fed rats received liquid diet ad libitum containing 37.5% ethanol-derived calories (6.7% volume/volume), and the pair-fed rats received the same volume of diet containing isocaloric amounts of maltose-dextrin substituted for ethanol for 3 or 28 days. Arterial blood pressure was evaluated in a separate group of rats, which was unchanged by 3 days, but elevated by 21% after 28 days of ethanol consumption. Vasopressin immunoreactivity and mRNA signal were not detected in the ganglia, nor were they changed in the nucleus tractus solitarius and paraventricular hypothalamic nucleus, by 3 days of ethanol consumption. However, after 28 days of ethanol liquid diet consumption, vasopressin-positive terminals were decreased in the nucleus tractus solitarius and vasopressin immunoreactivity cell bodies and mRNA signal were decreased in the paraventricular hypothalamic nucleus. Neuropeptide Y-immunoreactive terminals were increased in the nucleus tractus solitarius only after 28 days of ethanol liquid diet consumption, but they were decreased in the paraventricular hypothalamic nucleus in rats treated with ethanol for 3 or 28 days. We concluded that the levels of both vasopressin and neuropeptide Y neurotransmitters are changed by long-term ethanol consumption in the neuronal pathways related to control of blood pressure.
机译：先前研究的结果表明，乙醇会影响控制血压的中枢神经机制。我们研究了乙醇摄入对孤束核和室旁下丘脑核以及大鼠结节和结节神经节中血管加压素和神经肽Y免疫反应性及mRNA表达的影响。用乙醇喂养的大鼠随意饮食，其饮食中含有37.5％乙醇衍生的卡路里（6.7％体积/体积），而成对喂养的大鼠则接受相同体积的饮食，其中饮食中含有等热量的麦芽糖糊精替代了3或3的乙醇。 28天在另一组大鼠中评估了动脉血压，该血压在3天后没有变化，但在饮酒28天后升高了21％。饮酒3天后，未在神经节中检测到加压素的免疫反应性和mRNA信号，在孤束核和下丘脑室旁核中也未发现它们。但是，在饮用乙醇流质饮食28天后，孤束核中的血管加压素阳性末端减少，而下丘脑室旁核中的加压素免疫反应性细胞体减少，mRNA信号减少。仅在饮酒28天后，孤束核中的神经肽Y免疫反应性末端增加，而用乙醇处理3天或28天的大鼠下丘脑旁核中神经肽Y免疫反应性末端减少。我们得出结论，在与血压控制有关的神经元途径中，长期乙醇消耗会改变血管加压素和神经肽Y神经递质的水平。

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