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首页> 外文期刊>Alcohol >Sugar-dependent rats show enhanced intake of unsweetened ethanol.
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Sugar-dependent rats show enhanced intake of unsweetened ethanol.

机译：糖依赖性大鼠显示出不加糖乙醇的摄入增加。

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Rats show signs of dependence on sugar when it is available intermittently, including bingeing, withdrawal, and cross-sensitization with amphetamine. In the current study, we sought to determine whether sugar-dependent rats would show increased intake of unsweetened ethanol and, conversely, whether intermittent access to ethanol would augment sugar consumption. In Experiment 1, with intermittent versus ad libitum access to ethanol, Sprague-Dawley rats were given escalating concentrations of ethanol (1%, 2%, 4%, 7%, and 9%) over the course of 20 days. Rats in the intermittent ethanol access group, with 12-h daily access, consumed more 4%, 7%, and 9% ethanol during the first hour of access, and more 9% ethanol daily, than did rats in the ad libitum ethanol access group. In Experiment 2, with ethanol as a gateway to sugar intake, the rats from Experiment 1 were switched to 10% sucrose with 12-h daily access for 1 week. Rats in the intermittent ethanol access group consumed significantly more sugar than was consumed by rats in a control group with no prior ethanol experience. In Experiment 3, with sugar as a gateway to ethanol to determine whether sugar dependence leads to increased ethanol intake, four groups were maintained for 21 days according to the following designations: intermittent access to sugar and chow, ad libitum access to sugar and chow, intermittent access to chow, or ad libitum access to chow. Four days later, all groups were switched to intermittent ethanol access, as described in Experiment 1. The group with intermittent access to sugar and chow consumed the most 9% ethanol, supporting the suggestion that sugar dependence alters a rat's proclivity to drink ethanol. These results may relate to the co-morbidity between binge-eating disorders and alcohol intake and the tendency of people abstaining from alcohol to consume excessive amounts of sugar. In conclusion, bingeing on either ethanol or sugar fosters intake of the other.
机译：当间歇性地使用糖时，大鼠表现出对糖的依赖性，包括暴饮暴食，戒断和与苯丙胺的交叉敏化。在当前的研究中，我们试图确定糖依赖性大鼠是否会显示出不加糖的乙醇摄入量增加，反之，是否间歇性地获取乙醇会增加糖的消耗。在实验1中，间歇性地与随意地接触乙醇，在20天的过程中，对Sprague-Dawley大鼠给予了逐渐升高的乙醇浓度（分别为1％，2％，4％，7％和9％）。每天进出12h的间歇性乙醇进给组的大鼠比随意进出乙醇的大鼠进食的头一小时消耗更多的4％，7％和9％的乙醇，每天消耗更多的9％的乙醇。组。在实验2中，以乙醇作为糖摄入的途径，将实验1的大鼠换成10％蔗糖，每天服用12小时，持续1周。与没有乙醇经验的对照组相比，间歇性乙醇进入组的大鼠消耗的糖明显多于对照组。在实验3中，以糖作为通向乙醇的途径，以确定糖的依赖性是否会导致乙醇摄入量的增加，根据以下名称将四组维持21天：间歇性获取糖和食物，随意获取糖和食物，间歇性地使用食物，或随意地使用食物。四天后，按照实验1中的描述，将所有组切换为间歇性使用乙醇。具有间歇性获取糖和食物的组消耗了最多9％的乙醇，这表明糖依赖性改变了大鼠饮用乙醇的倾向性的暗示。这些结果可能与暴饮暴食症和饮酒之间的合并症有关，以及戒酒者消耗过量糖的趋势。总之，对乙醇或糖的暴饮暴食会促进对方的摄入。

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