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首页> 外文期刊>Human fertility: journal of the British Fertility Society >The association of renin-angiotensinogen system genes polymorphisms and idiopathic recurrent pregnancy loss
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The association of renin-angiotensinogen system genes polymorphisms and idiopathic recurrent pregnancy loss

机译：肾素 - 血管紧张素生物学系统基因多态性和特发性复发妊娠损失的关联

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The most common complication of pregnancy is idiopathic recurrent pregnancy loss (RPL). To identify the contribution of gene polymorphisms to this condition, we evaluated the association between RPL and the angiotensinogen (AGT), angiotensin receptor 1 (AGTR1) and Angiotensinogen converting enzyme (ACE). In this case-control study, the frequency of AGT (rs4762 and rs699), AGTR1 (rs5186) and ACE insertion/deletion (rs4340) polymorphisms in 202 idiopathic RPL women was compared with 210 women with no history of abortion, using tetra-primer ARMS-PCR. Polymorphisms were analysed by logistic regression analysis according to inheritance models. The CT genotype of AGT rs4762, the CC genotype of AGT rs699 and the AC genotype of AGTR1 rs5186 in a co-dominant inheritance model were associated with idiopathic RPL (OR = 1.63, 95% CI = 1.07-2.49 of CT versus CC; OR = 5.97, 95% CI = 1.28-27.82 of CC versus TT; and OR = 1.99, 95% CI = 1.22-3.07 of AC versus AA). The allele frequency of AGT rs699 and AGTR1 rs5186 polymorphisms, but not AGT rs4762 and ACE rs4340 polymorphisms were significantly different between women with RPL patients and controls (p = 0.020, p = 0.003, p = 0.105 and p = 0.065, respectively). These results show that there is a significant relationship between AGT (rs699) and AGTR1 (rs5186) polymorphisms and idiopathic RPL in the Iranian population.
机译：怀孕最常见的并发症是特发性复发妊娠损失（RPL）。为了鉴定基因多态性对该条件的贡献，我们评估了RPL与血管紧张素（AGT），血管紧张素受体1（AGTR1）和血管紧张素转化酶（ACE）之间的关联。在这种情况下，在使用Tetra-Primer的210名患有缺陷史的210名患者中，AGT（RS4762和RS699），AGTR1（RS4762和RS699），AGTR1（RS4762和RS699），AGTR1（RS5186）和ACE插入/删除（RS4340）多态性进行比较武器-PCR。根据遗传模型通过逻辑回归分析分析多态性。 AGT RS4762的CT基因型，AGT RS699的CC基因型和共同遗传模型中Agtr1 RS5186的ACTR1 RS5186的AC基因型与特发性RPL（或= 1.63,95％CI = 1.07-2.49的CT与CC;或= 5.97,95％CI = 1.28-27.82的CC与TT;或= 1.99,95％CI = 1.22-3.07的AC与AA）。 AGT RS699和AGTR1 RS5186多态性等位基因频率，但不是AGT RS4762和ACE RS4340多态性在患有RPL患者和对照的女性之间显着差异（P = 0.020，P = 0.003，P = 0.105和P = 0.065）。这些结果表明，AGT（RS699）和AGTR1（RS5186）多态性与伊朗人群的特性关系之间存在显着关系。

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