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Theoretical investigation of axial and local particle size distribution on expanded bed adsorption process

机译：膨胀床吸附过程中轴向和局部粒径分布的理论研究

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摘要

The general rate model was developed and solved to describe protein adsorption in an expanded bed. The model takes into account axial variation of bed porosity, particle size distribution (PSD), external and intraparticle mass transfer, and dispersion in liquid and solid phase. The analysis of the influence of the model parameters on dynamic capacity (DC) was investigated. The simulation results showed that major impact on dynamic capacity is exerted by intraparticle mass transfer (particle diameter and pore diffusivity). The external mass transfer resistance and dispersion parameters have secondary effect on DC. The replacement of axial PSD by the mean particle diameter results in error in calculation of DC, which increases remarkably with the increase of mean particle diameter. The PSD can promote a very slow approaching of plateau concentration by breakthrough curves. It was shown also that axial bed porosity variation could. be replaced by average porosity with negligible error for DC calculations.
机译：通用速率模型已开发并求解，以描述蛋白质在膨胀床中的吸附。该模型考虑了床孔隙率的轴向变化，颗粒尺寸分布（PSD），外部和内部颗粒传质以及在液相和固相中的分散性。分析了模型参数对动态容量（DC）的影响。模拟结果表明，颗粒内传质（粒径和孔扩散率）对动态容量产生了重大影响。外部传质阻力和分散参数对直流具有次要影响。用平均粒径替换轴向PSD会导致DC的计算误差，该误差会随着平均粒径的增加而显着增加。 PSD可以通过突破曲线促进非常缓慢地接近高原浓度。还表明轴向床孔隙率变化可以。用平均孔隙率代替，对于DC计算，误差可以忽略不计。

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