Lentiviral Vectors Pseudotyped with Envelope Glycoproteins Derived from Human Parainfluenza Virus Type 3

Cindy Jung; Bradley N.Grzybowski; Suxiang Tong; LiTeng Cheng; Richard W.Compans; Joseph M.Le Doux

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Lentiviral Vectors Pseudotyped with Envelope Glycoproteins Derived from Human Parainfluenza Virus Type 3

机译：伪装从人类副流感病毒3型衍生的包膜糖蛋白的慢病毒载体

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We describe the generation of lentiviruses pseudotyped with human parainfluenza type 3 envelope(HPIV3)glycoproteins.Lentivirus particles,expressed in 293T/17 cells,incorporate HPIV3 hemagglutinin-neuraminidase(HN)and fusion(F)proteins into their lipid bilayers and are able to transduce human kidney epithelial cells and polarized MDCK cells.Nfturaminidase,AZT,and anti-HPIV3 antisera block trans-duction,which is consistent with lentiviral-mediated transduction via sialated receptors for HPIV3.Our findings show that HPIV3 pseudotyped lentiviruses can be formed and may have a number of useful properties for human gene transfer.

机译：我们描述了用人副流感3型包膜（HPIV3）糖蛋白假型化的慢病毒的产生。在293T / 17细胞中表达的慢病毒颗粒，将HPIV3血凝素-神经氨酸酶（HN）和融合（F）蛋白掺入了其脂质双层中，并且能够转导人肾脏上皮细胞和极化的MDCK细胞。Nfturaminidase，AZT和抗HPIV3抗血清阻滞转导，与慢病毒通过唾液酸化的唾液酸受体介导的转导一致。我们的发现表明，HPIV3假型慢病毒可以形成并且可能对人类基因转移具有许多有用的特性。

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《Biotechnology Progress》 |2004年第6期|共7页
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Cindy Jung; Bradley N.Grzybowski; Suxiang Tong; LiTeng Cheng; Richard W.Compans; Joseph M.Le Doux;
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中图分类生物工程学（生物技术）;
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1. Lentiviral Vectors Pseudotyped with Envelope Glycoproteins Derived from Human Parainfluenza Virus Type 3 [J] . Cindy Jung, Bradley N.Grzybowski, Suxiang Tong, Biotechnology Progress . 2004,第6期

机译：伪装从人类副流感病毒3型衍生的包膜糖蛋白的慢病毒载体
2. Pseudotyping of lentiviral vector with novel vesiculovirus envelope glycoproteins derived from Chandipura and Piry viruses [J] . Hu Shuang, Kumar Dipu Mohan, Sax Chelsea, Virology . 2016,第Null期

机译：慢病毒载体的假期型与新的vesiculovirus封套糖蛋白衍生自沙莲属和piry病毒的糖蛋白
3. Pseudotyping of lentiviral vector with novel vesiculovirus envelope glycoproteins derived from Chandipura and Piry viruses [J] . Hu Shuang, Kumar Dipu Mohan, Sax Chelsea, Virology . 2016,第Null期

机译：慢病毒载体的假病毒分型使用源自Chandipura和Piry病毒的新型小泡病毒包膜糖蛋白
4. Lentivirus vector pseudotyped with human parainfluenza virus type 3 glycoproteins [C] . Grzybowski, B., Tong, . 2002

机译：用人副流感病毒3型糖蛋白假型化的慢病毒载体
5. HIV-1-derived lentiviral vectors pseudotyped with envelope glycoproteins derived from Ross River virus and Semliki Forest virus. [D] . Kahl, Christoph Adrian. 2003

机译：用源自罗斯河病毒和塞姆利基森林病毒的包膜糖蛋白假型化HIV-1衍生的慢病毒载体。
6. Human Immunodeficiency Virus Type 1-Derived Lentivirus Vectors Pseudotyped with Envelope Glycoproteins Derived from Ross River Virus and Semliki Forest Virus [O] . Christoph A. Kahl, Jon Marsh, Joanne Fyffe, 2004

机译：人免疫缺陷病毒1型慢病毒载体与罗斯河病毒和Semliki森林病毒衍生的包膜糖蛋白假型化
7. Human Immunodeficiency Virus Type 1-Derived Lentivirus Vectors Pseudotyped with Envelope Glycoproteins Derived from Ross River Virus and Semliki Forest Virus [O] . Kahl, Christoph A., Marsh, Jon, Fyffe, Joanne, 2004

机译：人免疫缺陷病毒1型慢病毒载体与罗斯河病毒和Semliki森林病毒衍生的包膜糖蛋白假型化
8. Characterization and Enhanced Processing of Soluble, Oligomeric GP140 Envelope Glycoproteins Derived from Human Immunodeficiency Virus Type-1 Primary Isolates [R] . Jones-Trower, A. Y. 2001

机译：人类免疫缺陷病毒1型初级分离株衍生的可溶性寡聚Gp140包膜糖蛋白的表征和增强加工

Lentiviral Vectors Pseudotyped with Envelope Glycoproteins Derived from Human Parainfluenza Virus Type 3

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