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首页> 外文期刊>Alcohol >Alcohol consumption and cerebral blood flow among older adults.
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Alcohol consumption and cerebral blood flow among older adults.

机译：老年人饮酒和脑血流量。

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A substantial epidemiological literature now supports the existence of a J or U-shaped association between alcohol consumption and a broad range cardiovascular health outcomes including stroke. Although it is well documented that alcoholics exhibit both global and regional cerebral hypoperfusion in the sober state, little is known regarding the effects of a broader range of alcohol consumption on cerebral blood flow (CBF). The present study employed positron emission tomography with H(2)(15)O to assess quantitative global and regional CBF in 86 participants (51 men and 35 women; mean age 60.1) as a function of self-reported weekly alcohol consumption (none, 1, 1 to 7, 7 to 15, and 15 drinks per week). Analyses controlling for age, gender, and vascular health (carotid intima-media thickness) revealed that, relative to the weighted population mean, global CBF was greater in the lightest alcohol consumption group (1 per week) and lower in the heaviest (15 per week). Effects did notvary across regions of interest. This report is the first to describe an inverted J-shaped relationship between alcohol consumption and CBF in the absence of stroke.
机译：现在，大量流行病学文献支持饮酒与包括中风在内的广泛心血管健康结果之间存在J形或U形关联。尽管有充分的文献证明，酗酒者在清醒状态下表现出整体和局部的脑灌注不足，但对于范围更广的饮酒对脑血流（CBF）的影响知之甚少。本研究采用正电子发射断层显像与H（2）（15）O来评估86名参与者（51名男性和35名女性;平均年龄60.1）中定量的全球和区域CBF，这是自我报告的每周饮酒量的函数（无，每周<1、1至<7、7至<15和> 15杯饮料）。对年龄，性别和血管健康（颈动脉内膜中层厚度）进行控制的分析显示，相对于加权人口平均值，最轻度饮酒组（每周<1）的总体脑血流量较高，最重度饮酒组的总体脑血流量较低（>每周15个）。效果在感兴趣的区域之间没有变化。该报告是第一个描述在没有中风的情况下饮酒量与CBF之间呈倒J型关系的报告。

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