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首页> 外文期刊>Development and psychopathology >Prenatal programming of postnatal plasticity revisited—And extended
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Prenatal programming of postnatal plasticity revisited—And extended

机译：后期可塑性的产前编程重新审视 - 延长

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Two sets of evidence reviewed herein, one indicating that prenatal stress is associated with elevated behavioral and physiological dysregulation and the other that such phenotypic functioning is itself associated with heightened susceptibility to positive and negative environmental influences postnatally, raises the intriguing hypothesis first advanced by Pluess and Belsky (2011) that prenatal stress fosters, promotes, or “programs” postnatal developmental plasticity. Here we review further evidence consistent with this proposition, including new experimental research systematically manipulating both prenatal stress and postnatal rearing. Collectively this work would seem to explain why prenatal stress has so consistently been linked to problematic development: stresses encountered prenatally are likely to continue postnatally, thereby adversely affecting the development of children programmed (by prenatal stress) to be especially susceptible to environmental effects. Less investigated are the potential benefits prenatal stress may promote, due to increased plasticity, when the postnatal environment proves to be favorable. Future directions of research pertaining to potential mechanisms instantiating postnatal plasticity and moderators of such prenatal-programming effects are outlined.
机译：这里审查的两组证据，表明产前应激与升高的行为和生理失调相关，另一个表型功能本身与原期然的对阳性和负面环境影响的易感性有关，提高了由Pluess先进的有趣假设Belsky（2011）普遍存在压力促进，促进或“课程”产后发育可塑性。在这里，我们审查了与此命题一致的进一步证据，包括系统地操纵产前压力和产后饲养的新实验研究。总而言之，这项工作似乎可以解释为什么产前压力如此始终如一地与问题的发展联系起来：遇到经过处理的压力可能会在后期开展，从而不利地影响所编制的儿童（通过产前压力）的发展，特别容易受到环境影响。较少研究的潜在益处产前压力可能会促进，因为随可塑性增加，当出生后环境被证明是有利的。概述了与潜在机制有关的未来研究方向，实例化了产前编程效应的产前塑性和主持人。

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