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首页> 外文期刊>Development and psychopathology >Prenatal intimate partner violence exposure predicts infant biobehavioral regulation: Moderation by the brain-derived neurotrophic factor (BDNF) gene
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Prenatal intimate partner violence exposure predicts infant biobehavioral regulation: Moderation by the brain-derived neurotrophic factor (BDNF) gene

机译：产前亲密的合作伙伴暴力暴露预测婴儿生物健康调节：脑源性神经营养因子（BDNF）基因的适度

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摘要

The ability to regulate stress is a critical developmental milestone of early childhood that involves a set of interconnected behavioral and physiological processes and is influenced by genetic and environmental stimuli. Prenatal exposure to traumatic stress and trauma, including intimate partner violence (IPV), increases risk for offspring biobehavioral regulation problems during childhood and adolescence. Although individual differences in susceptibility to prenatal stress have been largely unexplored, a handful of studies suggest children with specific genetic characteristics are most vulnerable to prenatal stress. We evaluated the brain-derived neurotrophic factor Val66Met gene (BDNF) as a moderator of the effect of prenatal IPV exposure on infant temperamental and cortisol regulation in response to a psychosocial challenge. Ninety-nine mother–infant dyads recruited from the community were assessed when infants (51% female) were 11 to 14 months. Maternal reports of IPV during pregnancy and infant temperament were obtained, and infant saliva was collected for genotyping and to assess cortisol reactivity (before and after the Strange Situation Task). Significant genetic moderation effects were found. Among infants with the BDNF Met allele, prenatal IPV predicted worse temperamental regulation and mobilization of the cortisol response, while controlling for infant postnatal exposure to IPV, other maternal traumatic experiences, and infant sex. However, prenatal IPV exposure was not associated with temperamental or cortisol outcomes among infant carriers of the Val/Val genotype. Findings are discussed in relation to prenatal programming and biological susceptibility to stress.
机译：调节压力的能力是儿童早期的关键发育里程碑，涉及一组相互联系的行为和生理过程，受到遗传和环境刺激的影响。产前暴露于创伤性应力和创伤，包括亲密的合作伙伴暴力（IPV），增加了儿童和青春期的后代生物健康调节问题的风险。虽然对产前压力的易感性的个体差异在很大程度上是未开发的，但是少数研究表明具有特异性遗传特征的儿童最容易受孕产胁迫。我们评估了脑衍生的神经营养因子Val66mmet基因（BDNF）作为产前IPV暴露对婴儿缘和皮质醇调节的影响的主持人，以应对心理社会挑战。当婴儿（51％的女性）为11至14个月时，评估从社区招募的九十九个母婴二元。获得妊娠期间IPV和婴儿气质的母体报告，并收集婴儿唾液进行基因分型，并评估皮质醇反应性（奇怪情况前后任务）。发现了显着的遗传促进效果。在BDNF符合BDNF的婴儿中，产前IPV预测了越来越糟的皮质醇反应，同时控制婴儿出生后暴露于IPV，其它产妇创伤体验和婴儿性别。然而，产前IPV暴露与Val / Val基因型的婴儿携带者之间的气质或皮质醇结果无关。研究结果是关于产前编程和生物易感性对压力的讨论。

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