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首页> 外文期刊>Diabetic medicine: A journal of the British Diabetic Association >Clinical risk factors for depressive syndrome in Type 2 diabetes: the Fremantle Diabetes Study
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Clinical risk factors for depressive syndrome in Type 2 diabetes: the Fremantle Diabetes Study

机译：2型糖尿病抑郁症患者的临床危险因素：Fremantle糖尿病研究

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Abstract Aims To identify early clinical predictors of depressive syndrome in people with Type 2 diabetes. Methods Depressive syndrome was assessed in 325 individuals with Type 2 diabetes 15 years after a baseline assessment, which included information on antidepressant use and depressive symptoms obtained using a quality‐of‐life scale. Follow‐up current and lifetime depressive syndrome were assessed using the nine‐item Patient Health Questionnaire and the Brief Lifetime Depression Scale and taking account of antidepressant use. Analyses were conducted inclusive and exclusive of antidepressant use where Patient Health Questionnaire criteria were not met. Results At baseline, the participants were aged 57.2±9.3 years and the median (interquartile range) diabetes duration was 2.2 (0.6–6.0) years. After a mean of 14.7±1.1 years’ follow‐up, 81 participants (24.9%) had depressive syndrome (14.8% defined by the Patient Health Questionnaire, 10.2% defined by antidepressants) and 31.4% reported lifetime depression, and in 10.2% of participants this preceded diabetes onset. With logistic regression (inclusive of antidepressants), follow‐up depressive syndrome was negatively associated with education level [odds ratio 0.39 (95% CI 0.20–0.75)] and antidepressant use [odds ratio 0.11 (95% CI 0.03–0.36)] and was positively associated with depression history before diabetes onset [odds ratio 2.79 (95% CI 1.24–6.27)]. In the model exclusive of antidepressants, depressive syndrome was positively associated with baseline depressive symptoms [odds ratio 2.57 (95% CI 1.32–5.03)] and antidepressant use [odds ratio 3.54 (95% CI 1.20–10.42)] and was negatively associated with education level [odds ratio 0.39 (95% CI 0.19–0.81)]. Conclusions Risk factors for depressive syndrome can be identified early after the onset of Type 2 diabetes. The early presence of depressive symptoms or its treatment and/or history of depression are likely indicators of vulnerability. Early risk stratification for late depressive syndrome is feasible in people with Type 2 diabetes and could assist with depression treatment or prevention.
机译：摘要旨在鉴定2型糖尿病人中抑郁症的早期临床预测因子。方法在基线评估15年后，在325名患有2型糖尿病的325名中评估了抑郁症综合征，其中包括使用寿命质量的抗抑郁用途和抑郁症状的信息。使用九项患者健康问卷和简短的寿命抑郁尺度和考虑到抗抑郁用途评估后续电流和终身抑郁症。分析是包容性的，不符合患者健康问卷标准的抗抑郁药用。结果在基线，参与者年龄57.2±9.3岁，中位数（侧链）糖尿病持续时间为2.2（0.6-6.0）岁。经过14.7±1.1岁的后续行动，81名参与者（24.9％）抑郁症（14.8％由患者健康调查问卷，10.2％由抗抑郁剂定义）和31.4％报告的终身抑郁症，10.2％参与者此前面的糖尿病发作。具有逻辑回归（包括抗抑郁药物），随访抑郁症与教育水平负相关[赔率比0.39（95％CI 0.20-0.75）]和抗抑郁用途[差距为0.11（95％CI 0.03-0.36）]和在糖尿病发病之前与抑郁症历史呈正相关[赔率比2.79（95％CI 1.24-6.27）]。在不同抗抑郁药的模型中，抑郁症与基线抑郁症状呈正相关[赔率比2.57（95％CI 1.32-5.03）]和抗抑郁药使用[差距3.54（95％CI 1.20-10.42），并与之相关教育水平[赔率比0.39（95％CI 0.19-0.81）]。结论2型糖尿病发作后早期抑郁综合征的危险因素可以鉴定。抑郁症状的早期存在或其治疗和/或抑郁病史可能是脆弱性的指标。晚期抑郁综合征的早期风险分层是2型糖尿病的人是可行的，可以帮助抑郁症治疗或预防。

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