Neuropsychologic assessment in collaborative Parkinson's disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson's Disease Research at the University of Pennsylvania and the University of Washington

WatsonG.S.; CholertonB.A.; GrossR.G.; WeintraubD.; ZabetianC.P.; TrojanowskiJ.Q.; MontineT.J.; SiderowfA.; LeverenzJ.B.

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Neuropsychologic assessment in collaborative Parkinson's disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson's Disease Research at the University of Pennsylvania and the University of Washington

机译：帕金森氏病合作研究中的神经心理学评估：美国国家神经病学会和中风研究所的建议宾夕法尼亚大学和华盛顿大学帕金森氏病研究卓越中心Morris K. Udall

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Cognitive impairment (CI) and behavioral disturbances can be the earliest symptoms of Parkinson's disease (PD), ultimately afflict the vast majority of PD patients, and increase caregiver burden. Our two Morris K. Udall Centers of Excellence for Parkinson's Disease Research were supported by the National Institute of Neurological Disorders and Stroke (NINDS) in an effort to recommend a comprehensive yet practical approach to cognitive and behavioral assessment to further collaborative research. We recommend a stepwise approach with two levels of standardized evaluation to establish a common battery, as well as an alternative testing recommendation for severely impaired subjects, and review supplemental tests that may be useful in specific research settings. Our flexible approach may be applied to studies with varying emphasis on cognition and behavior, does not place undue burden on participants or resources, and has a high degree of compatibility with existing test batteries to promote collaboration.

机译：认知障碍（CI）和行为障碍可能是帕金森氏病（PD）的最早症状，最终困扰着绝大多数PD患者，并增加了护理人员的负担。我们的两个Morris K. Udall帕金森氏病研究卓越中心得到了美国国家神经系统疾病和中风研究所（NINDS）的支持，旨在为认知和行为评估提供一种综合而实用的方法，以进一步开展协作研究。我们建议采用分步进行的方法，该方法应采用两个级别的标准化评估来建立通用电池，并为严重受损的受试者提供替代测试建议，并审查在特定研究环境中可能有用的补充测试。我们灵活的方法可以应用于对认知和行为的重视程度不同的研究，不会给参与者或资源造成不必要的负担，并且与现有的测试电池具有高度的兼容性以促进协作。

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《Alzheimer’s & dementia: the journal of the Alzheimer’s Association》 |2013年第5期|共6页
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WatsonG.S.; CholertonB.A.; GrossR.G.; WeintraubD.; ZabetianC.P.; TrojanowskiJ.Q.; MontineT.J.; SiderowfA.; LeverenzJ.B.;
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中图分类神经病学与精神病学;
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Neuropsychologic assessment in collaborative Parkinson's disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson's Disease Research at the University of Pennsylvania and the University of Washington

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