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首页> 外文期刊>Alcohol >Ethanol elimination rates in men and women in consideration of the calculated liver weight.
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Ethanol elimination rates in men and women in consideration of the calculated liver weight.

机译：考虑到计算出的肝脏重量，男女的乙醇清除率。

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摘要

The purpose of the study was to examine gender differences on the pharmacokinetics of ethanol. Sixty-eight healthy men and 64 healthy women with normal body mass indexes received between 0.79 and 0.95 g ethanol/kg body weight in the form of their choice after they had eaten a "typical" breakfast. The aimed concentration for both genders was a blood alcohol concentration C(0) of 0.104 g/dl. Blood samples in the elimination phase were taken in 10- to 20-min intervals beginning after completion of absorption. The maximum blood ethanol concentration was 0.0819+/-0.0184 g/dl for women and 0.0841+/-0.0155 g/dl for men. The hourly ethanol elimination rate, calculated over a linear function, in blood of 0.0179+/-0.0030 g/dl/h in women was significantly higher than the 0.0159+/-0.0029 g/dl/h for men (P<.0001). In relation to the liver weight, the hourly elimination rates were 5.008+/-0.678 g/kg liver/h for women and 4.854+/-0.659 g/kg liver/h for men, and were not statistically significant. The different liver masses as calculated in relation to the distribution volume account for the differing ethanol elimination rates between men and women.
机译：该研究的目的是检验乙醇药代动力学上的性别差异。体重指数正常的68位健康男性和64位健康女性在吃了“典型”早餐后，可以选择的形式接受0.79至0.95 g乙醇/ kg体重。这两个性别的目标浓度是血液酒精浓度C（0）为0.104 g / dl。消除阶段的血液样本在吸收完成后以10至20分钟的间隔进行采集。女性的最大血液乙醇浓度为0.0819 +/- 0.0184 g / dl，男性为0.0841 +/- 0.0155 g / dl。根据线性函数计算，女性血液中每小时乙醇的清除率为0.0179 +/- 0.0030 g / dl / h，明显高于男性的每小时0.0159 +/- 0.0029 g / dl / h（P <.0001） 。关于肝脏重量，女性每小时清除率为5.008 +/- 0.678 g / kg肝脏/小时，男性每小时清除率为4.854 +/- 0.659 g / kg肝脏/小时，但无统计学意义。相对于分布体积计算出的不同肝脏质量是男女之间乙醇清除率不同的原因。

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