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首页> 外文期刊>Alcohol >Effect of chronic ethanol administration on disposition of ethanol and its metabolites in rat.
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Effect of chronic ethanol administration on disposition of ethanol and its metabolites in rat.

机译：长期服用乙醇对大鼠乙醇及其代谢产物处置的影响。

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We studied the effects of chronic alcohol intake on the disposition of alcohol and its metabolites in the rat. We used male Wistar rats for all of the experiments in this study. Using a pair-feeding process, rats were fed a liquid diet containing alcohol or without alcohol for 6 weeks. Ethanol solutions (0.5, 1.0, 1.5, and 2.0 g/kg body weight [BW]) were administered as a bolus, intravenously. We then measured blood ethanol and acetate concentrations. Simultaneous multiline fitting was performed using mean blood alcohol concentration (BAC)-time curves fitted to the one-compartment open model with parallel first-order and Michaelis-Menten elimination kinetics. At low doses (0.5, 1.0, and 1.5 g/kgBW), no differences were observed between the alcohol group and the control group with respect to ethanol elimination rate, area under the curve of ethanol (AUC(EtOH)), and mean residence time of ethanol (MRT(EtOH)). At higher doses (2.0 g/kgBW), ethanol elimination rate in the alcohol group was significantly higher than in the control group (P<.5%). These findings were also substantiated by corresponding changes in AUC(EtOH) and MRT(EtOH). At low doses, no differences were observed between the alcohol group and the control group with respect to plateau concentration of acetate (AcT) (concentration of steady state=C(ss)AcT), area under the curve of AcT (AUC(AcT)), and mean residence time of AcT (MRT(AcT)). However, at higher doses, although there were no differences in C(ss)AcT, both AUC(AcT) and MRT(AcT) were significantly lower in the alcohol group when compared to the control group (P<.5%). Chronic alcohol consumption increases ethanol oxidation and AcT metabolism in rats, as observed at high blood alcohol concentrations (BACs). These effects were observed at BACs of 3.5-4.5 mg/ml, and were not observed at lower doses. Thus, with general alcohol consumption, interindividual differences and intra-individual changes in alcohol metabolism may not take into account increased or accelerated metabolism due to alcoholtolerance.
机译：我们研究了长期饮酒对大鼠酒精及其代谢产物处置的影响。在这项研究中，我们将雄性Wistar大鼠用于所有实验。使用成对喂养方法，给大鼠喂食含酒精或不含酒精的流质饮食6周。静脉推注乙醇溶液（0.5、1.0、1.5和2.0 g / kg体重[BW]）。然后，我们测量了血液中的乙醇和乙酸盐浓度。使用平均血液酒精浓度（BAC）-时间曲线拟合到具有平行一阶和Michaelis-Menten消除动力学的单室开放模型，同时进行多线拟合。在低剂量（0.5、1.0和1.5 g / kgBW）下，酒精组和对照组之间在乙醇消除率，乙醇曲线下面积（AUC（EtOH））和平均停留时间方面没有差异乙醇时间（MRT（EtOH））。在较高剂量（2.0 g / kgBW）下，酒精组的乙醇清除率显着高于对照组（P <.5％）。这些发现也被AUC（EtOH）和MRT（EtOH）的相应变化所证实。在低剂量下，酒精组和对照组之间在乙酸盐（AcT）的稳定浓度（稳态浓度= C（ss）AcT），AcT曲线下面积（AUC（AcT） ），以及AcT的平均停留时间（MRT（AcT））。但是，在较高剂量下，尽管C（ss）AcT的差异无统计学意义，但与对照组相比，酒精组的AUC（AcT）和MRT（AcT）均显着降低（P <.5％）。如在高血酒精浓度（BAC）下所观察到的，慢性酒精的消耗会增加大鼠的乙醇氧化和AcT代谢。在BAC为3.5-4.5 mg / ml时观察到这些作用，而在较低剂量下未观察到。因此，在一般饮酒的情况下，酒精代谢的个体差异和个体内部变化可能未考虑由于耐酒精性引起的代谢增加或加速。

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