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首页> 外文期刊>Alcohol >Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics.
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Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics.

机译：酒精中毒患者对乙酰氨基酚急性过量后的估计肝毒性风险。

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A published logistic regression model based on the Canadian Acetaminophen Overdose Study registry was used to calculate the risk of hepatotoxicity after an acute acetaminophen overdose and to estimate a treatment threshold line for alcoholic patients who did not co-ingest alcohol (i.e., abstinent alcoholics) on the Rumack-Matthew nomogram. The risk of hepatotoxicity in nonalcoholic and abstinent alcoholic patients was calculated at the acetaminophen concentration of 150 microg/ml at 4h (37.5 microg/ml at 12h) treatment threshold line. This corresponds to the "possible risk" line on the Rumack-Matthew nomogram and represents a 1.6% risk of hepatotoxicity for nonalcoholic patients at or below this line. At or below this same 150 microg/ml at 4-h line, abstinent alcoholic patients have a hepatotoxicity risk of 10.7%. The risk of hepatotoxicity in abstinent alcoholics' equivalent to that of nonalcoholics (i.e., 1.6%) occurs at a lower acetaminophen concentrations treatment threshold line, that is, 104 microg/ml at 4h (26 microg/ml at 12h). Because of difficulties plotting this new line on the familiar Rumack-Matthew semilogarithmic scale, a line connecting 100 microg/ml at 4h (25 microg/ml at 12h) is proposed. This line equates to a 1.1% risk of hepatotoxicity in abstinent alcoholic patients. The analysis supports the observation that based on the published model abstinent alcoholics might have a greater risk of hepatotoxicity after an acute acetaminophen overdose. This proposed new risk line can be used in hypothesis generation for future clinical studies in this alcohol related problem.
机译：基于加拿大对乙酰氨基酚过量研究注册中心的已发布逻辑回归模型用于计算急性对乙酰氨基酚过量后的肝毒性风险，并评估未与酒精合用（即戒酒）的酒精中毒患者的治疗阈值线Rumack-Matthew列线图。非酒精性和戒酒性酒精中毒的肝毒性风险是通过在4小时的对乙酰氨基酚浓度为150微克/毫升（12小时为37.5微克/毫升）时计算的。这对应于Rumack-Matthew诺模图上的“可能的风险”线，并表示在此线以下的非酒精性患者的肝毒性风险为1.6％。在4小时线达到或低于相同的150微克/毫升时，戒酒的酒精中毒患者的肝毒性风险为10.7％。戒酒者的酒精中毒风险与非酒精类药物相当（即1.6％），发生于对乙酰氨基酚浓度较低的治疗阈值线，即4h时104 microg / ml（12h时26 microg / ml）。由于难以在熟悉的Rumack-Matthew半对数标度上绘制此新线，因此建议在4h时连接100 microg / ml（在12h时为25 microg / ml）的线。这条线等同于戒酒者的肝毒性风险为1.1％。该分析支持以下观察：基于已发布的模型，在对乙酰氨基酚急性过量后，戒酒者可能具有更大的肝毒性风险。该拟议的新风险线可用于该假说的生成，以用于该酒精相关问题的未来临床研究。

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