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首页> 外文期刊>Alcohol >Intermittent binge alcohol exposure during the periadolescent period induces spatial working memory deficits in young adult rats.
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Intermittent binge alcohol exposure during the periadolescent period induces spatial working memory deficits in young adult rats.

机译：青春期期间间歇性暴饮暴饮会诱发年轻成年大鼠的空间工作记忆缺陷。

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摘要

Human and animal studies suggest adolescence is a period of heightened sensitivity to adverse cognitive sequelae of alcohol exposure. The present study assessed the effects of intermittent binge ethanol intoxication during the periadolescent period of Wistar rats on subsequent performance in a Morris water maze spatial navigation task. On postnatal days 32-56, rats were exposed to ethanol or air 3 days/week via vapor inhalation chambers. Acquisition of spatial navigation was assessed beginning 5 days after the final day of exposure, with 3 days of training in the Morris Water maze (four trials per day spaced at 90-s intertrial intervals [ITIs]). Rats were placed into the water maze at one of four positions along the perimeter, with a different release position to begin each trial. A probe trial assessed retention of platform location on the day after the final set of training trials. Four days after this probe trial, rats entered a working memory phase in which the platform was in a new location each day and a variable ITI of 1, 2, or 4 h was inserted between Trials 1 and 2; Trials 3 and 4 followed at 90-s intervals after Trial 2 on each day. The "savings" in latency to find the platform and distance traveled before finding it from Trial 1 to Trial 2 on each day served as an index of working memory. Ethanol-exposed rats showed similar acquisition of spatial navigation as control rats during training, as well as similar retention of platform location during the probe trial. However, rats exposed to average blood alcohol level (BAL) >200 mg% showed accelerated forgetting, with decreased retention of platform location at the 2-h ITI (P < .05), compared to control rats. Therefore, a 4-week history of intermittent ethanol exposure at BAL in excess of 200 mg% during periadolescence led to a working memory deficit in young adult rats, demonstrated by accelerated forgetting of novel information. These behavioral data are consistent with findings from adolescent human studies, indicating that binge-style alcohol exposure during the periadolescent stage of development is associated with deficits in retention of information.
机译：人类和动物研究表明，青春期是对酒精接触不良认知后遗症的高度敏感时期。本研究评估了Wistar大鼠青春期期间间歇性暴饮乙醇中毒对随后在Morris水迷宫空间导航任务中的表现的影响。在出生后第32-56天，每周3天通过蒸气吸入室将大鼠暴露于乙醇或空气中。在暴露的最后一天之后的5天开始评估空间导航的获取，并在Morris Water迷宫中进行3天的训练（每天四次试验，间隔90-s间隔[ITIs]）。将大鼠放在沿周边四个位置之一的水迷宫中，释放位置不同，以开始每个试验。探针试验评估了最后一组训练试验后第二天平台位置的保留情况。该探针试验后四天，大鼠进入工作记忆阶段，其中平台每天处于新位置，并且在试验1和2之间插入可变的ITI 1、2或4 h。每天进行2次试验之后，以3到90秒的间隔进行3和4试验。在每天从试验1到试验2之前找到平台和等待的距离的“节省”是工作内存的指标。在训练过程中，暴露于乙醇的大鼠显示出与对照大鼠相似的空间导航，并且在探针试验过程中保留了类似的平台位置。但是，与对照大鼠相比，暴露于平均血液酒精水平（BAL）> 200 mg％的大鼠表现出更快的遗忘，并且在2小时ITI时平台位置的保留降低（P <.05）。因此，在青春期期间，BAL间歇性乙醇暴露超过200 mg％的4周病史导致了幼年成年大鼠的工作记忆缺陷，这是由新信息的加速遗忘所证明的。这些行为数据与青春期人类研究的结果一致，表明在青春期发育阶段暴饮暴食酒精与信息保留不足有关。

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