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首页> 外文期刊>Alcohol >The effects of moderate neonatal ethanol exposure on eyeblink conditioning and deep cerebellar nuclei neuron numbers in the rat.
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The effects of moderate neonatal ethanol exposure on eyeblink conditioning and deep cerebellar nuclei neuron numbers in the rat.

机译：新生儿中度乙醇暴露对大鼠眨眼条件和深小脑核神经元数量的影响。

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Heavy, bingelike patterns of exposure to ethanol during a portion of the early postnatal period in the rat, a time of rodent brain development corresponding to the human third trimester, has been shown to deplete cerebellar neurons and to produce deficits in cerebellar-dependent tasks. In the current study, we examined the impact of more moderate ethanol exposure, during an extended portion of the rat third trimester equivalent, on cerebellar-dependent learning (eyeblink conditioning) and deep cerebellar nuclei neuron numbers. Neonatal rats received 0, 1, 2, or 3g/kg/day of ethanol in milk formula via a single intragastric intubation each day across postnatal days 2-11, or were left untreated. Peak BACs for ethanol-exposed rats were 50, 150, and 225 mg/dl, respectively. Rats underwent eyeblink conditioning as young adults (70 days of age) and deep cerebellar nuclei neuron numbers were assessed at 100 days of age. In Experiment 1, all rats showed normal responsiveness to periorbital stimulation prior toconditioning. The 3-g/kg/day group was impaired in eyeblink conditioning and possessed fewer deep cerebellar nuclei neurons. A trend toward impairment was observed in the 2-g/kg/day group. However, the 0-g/kg/day group was also impaired in eyeblink conditioning. In Experiment 2, the unconditioned stimulus pretest phase was eliminated, the 0-g/kg/day group learned normally, and both the 2- and 3-g/kg/day groups were again impaired. These results suggest that more moderate doses of ethanol during the rat third-trimester equivalent can produce long-term effects on the cerebellum.
机译：在大鼠的出生后早期，即与人类的三个月相适应的啮齿动物大脑发育的时期中，暴露于乙醇的沉重，暴饮暴食的模式已被证明会消耗小脑神经元并导致小脑依赖性任务的不足。在当前的研究中，我们研究了在大鼠晚期三个月的等效时间内，适度乙醇暴露对小脑依赖性学习（眨眼条件）和小脑核神经元深层数字的影响。新生大鼠在出生后2-11天每天每天通过一次胃内插管接受0、1、2或3g / kg /天的牛奶配方乙醇，或不进行治疗。暴露于乙醇的大鼠的峰值BAC分别为50、150和225 mg / dl。在年轻的成年人（70天龄）时对大鼠进行眨眼调节，并在100天龄时评估小脑深核神经元数量。在实验1中，所有大鼠在适应前均表现出对眶周刺激的正常反应。 3 g / kg /天的组眨眼条件受损，拥有较少的深小脑核神经元。在2-g / kg /天的组中观察到了损害的趋势。但是，0-g / kg /天组的眨眼条件也受损。在实验2中，取消了无条件刺激的预测试阶段，0-g / kg /天的组正常学习，而2和3g / kg /天的组均再次受损。这些结果表明，在大鼠孕中期，更适量的乙醇可以对小脑产生长期影响。

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