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首页> 外文期刊>Alcohol >Rates of ethanol metabolism decrease in sons of alcoholics following a priming dose of ethanol.
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Rates of ethanol metabolism decrease in sons of alcoholics following a priming dose of ethanol.

机译：初次服用乙醇后，酗酒者的儿子体内乙醇的代谢率会降低。

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摘要

Rapid changes in rates of ethanol metabolism in response to acute ethanol administration have been observed in animals and humans. To examine whether this phenomenon might vary by risk for alcoholism, 23 young men with a positive family history of alcoholism (family history positive [FHP]) were compared to 15 young men without a family history of alcoholism (family history negative [FHN]). Rates of ethanol metabolism were measured in all subjects first after an initial ethanol dose (0.85 g/kg) and then, several hours later, a second dose (0.3 g/kg), and the two rates were compared. The two groups of subjects were similar in their histories of ethanol consumption. FHP subjects demonstrated faster initial rates of ethanol metabolism, 148+/-36 mg/kg/h, compared to FHN subjects, 124+/-18 mg/kg/h, P=.01. However, FHN subjects increased their rate of metabolism by 10+/-27% compared to a decrease of -15+/-24% in FHP subjects, P=.007. Fifty-two percent of the FHP and none of the FHN subjects exhibited a decline in metabolic rate of 20% or more, P=.0008. Since a significant proportion of FHP subjects exhibited a decrease in the second rate of ethanol metabolism, these preliminary data might help to partly explain why FHP individuals differ in their sensitivity to ethanol and are more likely to develop alcohol dependence.
机译：在动物和人类中已经观察到响应于急性乙醇施用，乙醇代谢速率的快速变化。为了检查这种现象是否会因酗酒风险而有所不同，我们比较了23名酗酒家族史阳性的年轻男性（家族史为阳性[FHP]）与15名没有酗酒家族病史的年轻男性（家族史为阴性[FHN]） 。首先在初始乙醇剂量（0.85 g / kg）后测量所有受试者的乙醇代谢率，然后在数小时后第二次剂量（0.3 g / kg）测量乙醇代谢率，并比较这两种率。两组受试者的乙醇消耗历史相​​似。与FHN受试者124 +/- 18 mg / kg / h相比，FHP受试者表现出更快的乙醇代谢初始速率148 +/- 36 mg / kg / h，P = .01。但是，FHN受试者的代谢率提高了10 +/- 27％，而FHP受试者的代谢率降低了-15 +/- 24％，P = .007。 FHP的52％和FHN受试者均未出现20％或更高的代谢率下降，P = .0008。由于相当一部分FHP受试者表现出乙醇代谢的第二速率下降，因此这些初步数据可能有助于部分解释为什么FHP个人对乙醇的敏感性不同并且更可能发展为酒精依赖。

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