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首页> 外文期刊>Alcohol >Prenatal ethanol exposure alters core body temperature and corticosterone rhythms in adult male rats.
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Prenatal ethanol exposure alters core body temperature and corticosterone rhythms in adult male rats.

机译：产前乙醇暴露会改变成年雄性大鼠的核心体温和皮质酮节律。

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Ethanol's effects on the developing brain include alterations in morphology and biochemistry of the hypothalamus. To examine the potential functional consequences of ethanol's interference with hypothalamic differentiation, we studied the long-term effects of prenatal ethanol exposure on basal circadian rhythms of core body temperature (CBT) and heart rate (HR). We also examined the late afternoon surge in corticosterone (CORT). Core body temperature and HR rhythms were studied in separate groups of animals at 4, 8, and 20 months of age. The normal late afternoon rise in plasma CORT was examined in freely moving male rats at 6 months of age via an indwelling right atrial cannula. Results showed that the CBT circadian rhythm exhibited an earlier rise after the nadir of the rhythm in fetal alcohol-exposed (FAE) males at all ages compared to controls. At 8 months of age, the amplitude of the CBT circadian rhythm in FAE males was significantly reduced to the level observed in controls at 20 months. No significant effects of prenatal ethanol exposure were observed on basal HR rhythm at any age. The diurnal rise in CORT secretion was blunted and prolonged in 6-month-old FAE males compared to controls. Both control groups exhibited a robust surge in CORT secretion around the onset of the dark phase of the light cycle, which peaked at 7:30 p.m. Whereas FAE males exhibited a linear rise beginning in mid afternoon, which peaked at 9:30 p.m. These results indicate that exposure to ethanol during the period of hypothalamic development can alter the long-term regulation of circadian rhythms in specific physiological systems.
机译：乙醇对发育中的大脑的影响包括下丘脑的形态和生化改变。为了检查乙醇干扰下丘脑分化的潜在功能后果，我们研究了产前乙醇暴露对核心体温（CBT）和心率（HR）的基础昼夜节律的长期影响。我们还检查了皮质激素（CORT）在下午晚些时候激增。在4、8和20个月大的不同动物组中研究了核心体温和HR节律。通过留置的右心房插管在6个月大时自由移动的雄性大鼠中检查了血浆CORT的正常下午晚期升高。结果显示，与对照组相比，在所有年龄段的胎儿酒精暴露（FAE）男性中，CBT昼夜节律的节律都出现在最低点之后。在8个月大时，FAE雄性的CBT昼夜节律的幅度显着降低至20个月对照组中观察到的水平。在任何年龄，未观察到产前乙醇暴露对基础HR节律的显着影响。与对照组相比，在6个月大的FAE雄性中，CORT分泌的昼夜增加减弱并延长了。两个对照组在光周期的暗期开始时都表现出CORT分泌的强劲增加，在晚上7:30达到峰值。 FAE雄性从下午中旬开始呈线性上升，并在下午9:30达到峰值。这些结果表明在下丘脑发育期间暴露于乙醇可以改变特定生理系统中昼夜节律的长期调节。

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