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首页> 外文期刊>AJRI: American Journal of Reproductive Immunology >The skewed TCR-BV repertoire displayed at the maternal-fetal interface of women with unexplained pregnancy loss.
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The skewed TCR-BV repertoire displayed at the maternal-fetal interface of women with unexplained pregnancy loss.

机译：TCR-BV偏斜库显示在无法解释的妊娠丢失妇女的母胎界面上。

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PROBLEM: The study was undertaken to investigate T-cell receptor (TCR) variable beta (BV)-chain usage at maternal-fetal interface and explore the relationship between the skewed TCR-BV usage and unexplained pregnancy losses. METHOD OF STUDY: A total of 57 patients with unexplained pregnancy loss including 39 cases with unexplained spontaneous abortion and 18 cases with unexplained recurrent spontaneous abortion (RSA) were chosen in Renji Hospital, Shanghai Second Medical University matched with 41 women with normal pregnancies in first trimester between September 2002 and November 2003. A high-resolution spectratyping analysis of complementarity-determining region 3 (CDR3) was used to detect and compare the degree and pattern of TCR-BV repertoire usage at the maternal-fetal interface between patients with pregnancy loss and normal controls. RESULTS: There were two comparisons of TCR usage performed between patients and controls, which included the degree (mean value of every TCR-BVn expression) and thepattern (skewed TCR-BVn frequency). The skewed TCR-BVn is defined as an absolute BVn usage of > 5% calculated from the formula or a double increased BVn usage compared with the mean value of normal BVn. According to the degree of TCR-BV usage, BV2 (P = 0.046), BV10 (P = 0.016), and BV11 (P = 0.030) in spontaneous abortion group and BV19 (P = 0.038) in RSA group showed higher usage, while BV5.2 (P = 0.006 and P = 0.046) in both abortion groups showed significantly lower usage when compared with normal controls. About the pattern of skewed TCR-BV distribution, we found that TCR-BV2, -3, -6, and -7 were the four most common BV families in deciduas of patients with both types of abortion and normal controls. Women with spontaneous abortion demonstrated higher frequency of BV10 (P = 0.035) and lower frequencies of BV4 (P = 0.002) and BV5.2 (P = 0.003) in comparison with controls. In RSA, higher frequencies of BV15 (P = 0.018), BV19 (P = 0.049), and BV20 (P = 0.018), in the mean time, lower frequencies of BV4 (P = 0.026) and BV7 (P = 0.018) distributions were verified. CONCLUSIONS: Our results suggested that a significant skewed TCR-BV repertoire occurred at the maternal-fetal interface with patients undergoing abortion. The specific skewed usages of TCR-BV might be associated with the susceptibility to unexplained pregnancy loss.
机译：问题：这项研究旨在研究母胎界面的T细胞受体（TCR）可变β（BV）链使用情况，并探讨偏斜的TCR-BV使用情况与无法解释的妊娠损失之间的关系。研究方法：选择上海第二医科大学附属仁济医院共57例原因不明的妊娠流产患者，其中39例原因不明的自然流产和18例原因不明的自然流产（RSA），首先匹配41例正常妊娠的女性。在2002年9月至2003年11月之间的三个月中进行的研究。对互补决定区3（CDR3）进行了高分辨率的分型分析，以检测和比较妊娠丢失患者在母胎界面上TCR-BV保留成分的使用程度和模式和常规控件。结果：在患者和对照组之间进行了两次TCR使用情况的比较，包括程度（每个TCR-BVn表达的平均值）和模式（偏斜的TCR-BVn频率）。偏斜的TCR-BVn定义为：根据公式计算得出的绝对BVn使用率> 5％，或者与正常BVn的平均值相比，BVn使用率增加了一倍。根据TCR-BV的使用程度，自然流产组的BV2（P = 0.046），BV10（P = 0.016）和BV11（P = 0.030）和RSA组的BV19（P = 0.038）显示较高的使用率，而与正常对照组相比，两个堕胎组的BV5.2（P = 0.006和P = 0.046）均显示出较低的使用率。关于偏斜TCR-BV分布的模式，我们发现在流产类型和正常对照者的十足患者中，TCR-BV2，-3，-6和-7是四个最常见的BV家族。与对照组相比，自然流产的妇女表现出较高的BV10频率（P = 0.035）和较低的BV4频率（P = 0.002）和BV5.2（P = 0.003）。在RSA中，BV15（P = 0.018），BV19（P = 0.049）和BV20（P = 0.018）的较高频率，同时，BV4（P = 0.026）和BV7（P = 0.018）的较低频率分布经过验证。结论：我们的结果表明，在流产患者的母胎界面上出现了明显的TCR-BV偏斜库。 TCR-BV的特定偏斜用法可能与无法解释的妊娠丢失的易感性有关。

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