The SOS2-SCaBP8 Complex Generates and Fine-Tunes an AtANN4-Dependent Calcium Signature under Salt Stress

Ma Liang; Ye Jiamin; Yang Yongqing; Lin Huixin; Yue Lili; Luo Jin; Long Yu; Fu Haiqi; Liu Xiangning; Zhang Yulin; Wang Yi; Chen Liangyi; Kudla Joerg; Wang Youjun; Han Shengcheng; Song Chun-Peng; Guo Yan

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The SOS2-SCaBP8 Complex Generates and Fine-Tunes an AtANN4-Dependent Calcium Signature under Salt Stress

机译：SOS2-SCABP8复合物在盐胁迫下产生和微调Atann4依赖性钙签名

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Calcium signals act as universal second messengers that trigger many cellular processes in animals and plants, but how specific calcium signals are generated is not well understood. In this study, we determined that AtANN4, a putative calcium-permeable transporter, and its interacting proteins, SCaBP8 and SOS2, generate a calcium signal under salt stress, which initially activates the SOS pathway, a conserved mechanism that modulates ion homeostasis in plants under salt stress. After activation, SCaBP8 promotes the interaction of protein kinase SOS2 with AtANN4, which enhances its phosphorylation by SOS2. This phosphorylation of AtANN4 further increases its interaction with SCaBP8. Both the interaction with and phosphorylation of AtANN4 repress its activity and alter calcium transients and signatures in HEK cells and plants. Our results reveal how downstream targets are required to create a specific calcium signal via a negative feedback regulatory loop, thereby enhancing our understanding of the regulation of calcium signaling.

机译：钙信号充当普通的第二信使，它引发了动物和植物中的许多细胞过程，而是如何产生特定的钙信号是如何理解的。在这项研究中，我们确定Atann4，推定的钙渗透转运蛋白及其相互作用的蛋白质，ScABP8和SOS 2在盐胁迫下产生钙信号，其最初激活SOS途径，是一种调节植物中的离子稳定性的保守机制盐胁迫。激活后，ScaBP8促进蛋白激酶SOS2与Atann4的相互作用，其通过SOS 2增强其磷酸化。该Atann4的这种磷酸化进一步增加了与ScABP8的相互作用。 atann4的相互作用和磷酸化既抑制其活性和改变HEK细胞和植物的钙瞬变和签名。我们的结果揭示了下游目标是通过负反馈调节回路创建特定钙信号的，从而提高了我们对钙信号传导调节的理解。

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《Developmental cell》 |2019年第5期|共18页
作者
Ma Liang; Ye Jiamin; Yang Yongqing; Lin Huixin; Yue Lili; Luo Jin; Long Yu; Fu Haiqi; Liu Xiangning; Zhang Yulin; Wang Yi; Chen Liangyi; Kudla Joerg; Wang Youjun; Han Shengcheng; Song Chun-Peng; Guo Yan;
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作者单位

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R;

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R;

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R;

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R;

Beijing Normal Univ Coll Life Sci Beijing Key Lab Gene Resource &

Mol Dev Beijing Peoples R;

Beijing Normal Univ Coll Life Sci Beijing Key Lab Gene Resource &

Mol Dev Beijing Peoples R;

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R;

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R;

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R;

Peking Univ Inst Mol Med Lab Cell Secret &

Metab Beijing 100871 Peoples R China;

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R;

Peking Univ Inst Mol Med Lab Cell Secret &

Metab Beijing 100871 Peoples R China;

Univ Munster Inst Biol &

Biotechnol Pflanzen Schlosspl 4 D-48149 Munster Germany;

Beijing Normal Univ Coll Life Sci Beijing Key Lab Gene Resource &

Mol Dev Beijing Peoples R;

Beijing Normal Univ Coll Life Sci Beijing Key Lab Gene Resource &

Mol Dev Beijing Peoples R;

Henan Univ Collaborat Innovat Ctr Crop Stress Biol Inst Plant Stress Biol Kaifeng 475001 Henan;

China Agr Univ Coll Biol Sci State Key Lab Plant Physiol &

Biochem Beijing 100193 Peoples R;

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正文语种 eng
中图分类细胞生物学;
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专利

1. The SOS2-SCaBP8 Complex Generates and Fine-Tunes an AtANN4-Dependent Calcium Signature under Salt Stress [J] . Ma Liang, Ye Jiamin, Yang Yongqing, Developmental cell . 2019,第5期

机译：SOS2-SCABP8复合物在盐胁迫下产生和微调Atann4依赖性钙签名
2. Salt-stress secondary metabolite signatures involved in the ability of Casuarina glauca to mitigate oxidative stress [J] . Jorge Tiago F., Tohge Takayuki, Wendenburg Regina, Environmental and experimental botany . 2019,第期

机译：盐胁迫二次代谢物签名参与Casuarina glauca减轻氧化应激的能力
3. Roles of three Fusarium oxysporum calcium ion (Ca2+) channels in generating Ca2+ signatures and controlling growth [J] . Kim Hye-Seon, Kim Jung-Eun, Frailey Daniel, Fungal Genetics and Biology . 2015,第Null期

机译：三个尖镰孢钙离子（Ca2 +）通道在产生Ca2 +信号和控制生长中的作用
4. Synthesis of bioactive PMMA bone cement via modification with alkoxysilane and calcium salt: effect of calcium salt [C] . C. Ohtsuki, M. Kyomoto, T. Miyazaki, International Symposium on Ceramics in Medicine . 2002

机译：用烷氧基硅烷和钙盐改性合成生物活性PMMA骨水泥：钙盐的影响
5. General trends in the desolvation behavior of calcium salts and the characterization of mesomorphous calcium salts. [D] . Atassi, Faraj. 2007

机译：钙盐的去溶剂化行为和介晶钙盐表征的一般趋势。
6. The Actin-Related Protein2/3 Complex Regulates Mitochondrial-Associated Calcium Signaling during Salt Stress in Arabidopsis [O] . Yi Zhao, Zhen Pan, Yan Zhang, 2013

机译：肌动蛋白相关蛋白2/3复合物调节拟南芥盐胁迫期间线粒体相关的钙信号传导。
7. Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus. [O] . Alberto Muñoz, Margherita Bertuzzi, Jan Bettgenhaeuser, 2015

机译：通过水母蛋白介导的钙测量在烟曲霉的活细胞中报告不同的应激诱导的钙特征。
8. Stress Corrosion Cracking of Titanium Alloys Studies of Cracks in Thin Specimens Scc of Ti-6AL-4V IN Chloride, Iodide and Fluoride Solutions Stress Corrosion Cracking in Molten Salts Electrochemistry of Freshly Generated Titanium Surfaces [R] . Beck, T. R., Blackburn, M. J., Smyrl, W. H. 1971

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The SOS2-SCaBP8 Complex Generates and Fine-Tunes an AtANN4-Dependent Calcium Signature under Salt Stress

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