...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Digestive Diseases and Sciences >Intensive Pharmacy Care Improves Outcomes of Hepatitis C Treatment in a Vulnerable Patient Population at a Safety-Net Hospital
【24h】

Intensive Pharmacy Care Improves Outcomes of Hepatitis C Treatment in a Vulnerable Patient Population at a Safety-Net Hospital

机译：强化药房治疗在安全净医院的脆弱患者人群中改善了丙型肝炎治疗的结果

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BackgroundTreatment of hepatitis C virus (HCV) with direct-acting antiviral (DAA) regimens has resulted in high rates of sustained virologic response (SVR). Treatment of vulnerable populations may be improved by incorporating an on-site intensive specialty pharmacy (ON-ISP).AimsTo describe outcomes of HCV treatment at a safety-net hospital and proportion of subjects achieving SVR for those using the ON-ISP compared to an off-site pharmacy (OFF-SP).MethodsA retrospective cohort study of 219 subjects treated for HCV with DAA at Boston Medical Center was conducted. Subject characteristics, virologic response, and pharmacy services used were recorded. We used multivariable logistic regression to test the association between ON-ISP and SVR after adjusting for covariates.ResultsSVR occurred in 71% of subjects by intention-to-treat (73% among ON-ISP users vs 57% among OFF-SP users) and 95% completing treatment per-protocol (96% among ON-ISP users vs 87% among OFF-SP users). Adjustment for age, sex, ethnicity, insurance, fibrosis, prior treatment, and MELD revealed an increased likelihood of SVR among users of ON-ISP: OR 6.0 (95% CI 1.18-31.0). No significant difference in treatment delay or adverse events was seen among users of either pharmacy type.ConclusionsHCV treatment with DAA was well tolerated, but the rate of SVR was low (71%) compared to trials. This was due to loss to follow-up, as the per-protocol rate of SVR was much higher (95%). Use of ON-ISP was associated with an increase in SVR and may be valuable for improving care for vulnerable populations.
机译：丙型肝炎病毒（HCV）与直接作用抗病毒（DAA）方案的背景导致了持续的病毒性反应（SVR）的高率。可以通过纳入现场密集型专业药房（ON-ISP）。Maimsto描述了在安全净医院的HCV治疗的结果和使用ON-ISP的人进行了比例，描述了使用ON-ISP的患者的蛋白质治疗的结果。禁区药房（off-SP）.Methodsa回顾性队列对Boston Medical Cent中心的Daa治疗219名受试者的研究。记录了学科特征，病毒学反应和药房服务。我们使用多变量的逻辑回归来测试IN-ISP和SVR之间的关联，在调整Covariates后.ResultSSVR在71％的受试者中发生，意图治疗（ISP用户在IN-ISP用户中有73％，off-SP用户中有57％） 95％的每协议完成治疗（IN-ISP用户中96％，off-SP用户中的87％）。年龄，性别，种族，保险，纤维化，先前治疗和融合的调整显示，在ISP的用户中，SVR的可能性增加：或6.0（95％CI 1.18-31.0）。在任何药物类型的使用者中，观察到治疗延迟或不良事件没有显着差异。与DAA进行良好的耐受性，但与试验相比，SVR的速率低（71％）。这是由于随访丧失，因为SVR的每协定率高得多（95％）。使用ON-ISP与SVR的增加有关，对于改善弱势群体的护理可能是有价值的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号