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首页> 外文期刊>Digestive Diseases and Sciences >Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA
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Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA

机译：吸烟和炎症性肠病：中国，印度和美国的比较

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BackgroundCigarette smoking is thought to increase the risk of Crohn's disease (CD) and exacerbate the disease course, with opposite roles in ulcerative colitis (UC). However, these findings are from Western populations, and the association between smoking and inflammatory bowel disease (IBD) has not been well studied in Asia. AimsWe aimed to compare the prevalence of smoking at diagnosis between IBD cases and controls recruited in China, India, and the USA, and to investigate the impact of smoking on disease outcomes.MethodsWe recruited IBD cases and controls between 2014 and 2018. All participants completed a questionnaire about demographic characteristics, environmental risk factors and IBD history.ResultsWe recruited 337 participants from China, 194 from India, and 645 from the USA. In China, CD cases were less likely than controls to be current smokers (adjusted odds ratio [95% CI] 0.4 [0.2-0.9]). There was no association between current or former smoking and CD in the USA. In China and the USA, UC cases were more likely to be former smokers than controls (China 14.6 [3.3-64.8]; USA 1.8 [1.0-3.3]). In India, both CD and UC had similar current smoking status to controls at diagnosis. Current smoking at diagnosis was significantly associated with greater use of immunosuppressants (4.4 [1.1-18.1]) in CD cases in China.ConclusionsWe found heterogeneity in the associations of smoking and IBD risk and outcomes between China, India, and the USA. Further study with more adequate sample size and more uniform definition of smoking status is warranted.
机译：BackgroundCigarette吸烟被认为增加克罗恩病（CD）的风险（CD），加剧了疾病课程，在溃疡性结肠炎（UC）中具有相反的作用。然而，这些发现来自西方人群，吸烟和炎症性肠病（IBD）之间的关联尚未在亚洲进行很好地研究。 AIMSWE旨在比较中国，印度和美国招募的IBD病例和控制诊断的患病率，并调查吸烟对疾病的影响。招聘2014年和2018年之间的IBD病例和控制。所有参与者完成关于人口统计学特征，环境风险因素和IBD历史的问卷。培训来自中国的337名参与者，194年，来自印度，645名来自美国。在中国，CD案例不太可能是当前吸烟者的控制（调整的赔率比[95％CI] 0.4 [0.2-0.9]）。当前或以前的吸烟和美国在美国之间没有关联。在中国和美国，UC案件更有可能是前吸烟者而不是控制（中国14.6 [3.3-64.8];美国1.8 [1.0-3.3]）。在印度，CD和UC都有类似的当前吸烟状态，以控制诊断。在诊断时，目前的吸烟与中国的CD病例中的免疫抑制剂（4.4 [1.1-18.1]）显着相关有必要进一步研究更具足够的样品尺寸和更均匀的吸烟状态定义。

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  • 来源
    《Digestive Diseases and Sciences》 |2018年第10期|共11页
  • 作者

    Wang Peiqi; Hu Jun; Ghadermarzi Shadi; Raza Ali; OConnell Douglas; Xiao Amy; Ayyaz Faraz; Zhi Min; Zhang Yuanqi; Parekh Nimisha K.; Lazarev Mark; Parian Alyssa; Brant Steven R.; Bedine Marshall; Truta Brindusa; Hu Pinjin; Banerjee Rupa; Hutfless Susan M.;

  • 作者单位

    Johns Hopkins Univ Dept Surg Baltimore MD USA;

    Sun Yat Sen Univ Affiliated Hosp 6 Dept Gastroenterol Guangzhou Guangdong Peoples R China;

    East Carolina Univ Dept Internal Med Greenville NC 27858 USA;

    Harvard Med Sch Boston Childrens Hosp Dept Cardiol Boston MD USA;

    Univ Calif Irvine Sch Med Div Gastroenterol Irvine CA 92717 USA;

    Johns Hopkins Univ Whiting Sch Engn Dept Biomed Engn Baltimore MD USA;

    Serv Inst Med Sci Lahore Pakistan;

    Sun Yat Sen Univ Affiliated Hosp 6 Dept Gastroenterol Guangzhou Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 6 Dept Gastroenterol Guangzhou Guangdong Peoples R China;

    Univ Calif Irvine Sch Med Div Gastroenterol Irvine CA 92717 USA;

    Johns Hopkins Univ Dept Med Div Gastroenterol &

    Hepatol Meyerhoff Inflammatory Bowel Dis Ctr;

    Johns Hopkins Univ Dept Med Div Gastroenterol &

    Hepatol Meyerhoff Inflammatory Bowel Dis Ctr;

    Univ Med &

    Dent New Jersey Rutgers Hlth Dept Med Div Gastroenterol &

    Hepatol New Brunswick NJ;

    Johns Hopkins Univ Dept Med Div Gastroenterol &

    Hepatol Meyerhoff Inflammatory Bowel Dis Ctr;

    Johns Hopkins Univ Dept Med Div Gastroenterol &

    Hepatol Meyerhoff Inflammatory Bowel Dis Ctr;

    Sun Yat Sen Univ Affiliated Hosp 6 Dept Gastroenterol Guangzhou Guangdong Peoples R China;

    Asian Inst Gastroenterol Hyderabad India;

    Johns Hopkins Univ Div Gastroenterol &

    Hepatol Gastrointestinal Epidemiol Res Ctr 600 N Wolfe St;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 消化系及腹部疾病;
  • 关键词

    Smoking; Crohn's disease; Ulcerative colitis; Asia; Environment;

    机译：吸烟;克罗恩病;溃疡性结肠炎;亚洲;环境;

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