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HLA DRB1*13 as a risk factor for type 1 autoimmune hepatitis in North American patients.

机译:HLA DRB1 * 13作为北美患者1型自身免疫性肝炎的危险因素。

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Our goal was to determine if HLA DRB1*13 is associated with autoimmune hepatitis in North American patients. Two hundred and ten adults with definite type 1 autoimmune hepatitis were typed by DNA-based techniques, and the frequency of HLA DRB1*13 in patients without DRB1*03 and DRB1*04 was compared to that in 396 patients with eight other chronic liver diseases and 102 normal individuals. HLA DRB1*13 occurred more commonly in the autoimmune patients who lacked DRB1*03 and DRB1*04 than normal subjects who were similarly restricted (56% vs. 27%, P = 0.007). The frequency of HLA DRB1*13 was higher in autoimmune patients without DRB1*03 and DRB1*04 than in patients with other chronic liver diseases who were similarly restricted (59% vs. 32%, P = 0.01). Only patients with primary sclerosing cholangitis had a comparable occurrence of HLA DRB1*13. In conclusion, HLA DRB1*13 may be a genetic risk factor for some white North American patients with type 1 autoimmune hepatitis.
机译:我们的目标是确定HLA DRB1 * 13是否与北美患者的自身免疫性肝炎有关。 通过基于DNA的技术键入二百一十个具有明确的自身免疫性肝炎的成年人,并将HLA DRB1 * 13在没有DRB1 * 03和DRB1 * 04的患者中的频率与其他慢性肝病的396名患者 和102个正常人。 HLA DRB1 * 13更常见于自身免疫性患者,缺乏DRB1 * 03和DRB1 * 04的正常受试者,他类似地限制(56%与27%,P = 0.007)。 HLA DRB1 * 13的频率在没有DRB1 * 03和DRB1 * 04的自身免疫患者中高于与其他慢性肝脏疾病的患者相似受限制(59%,P = 0.01)。 只有初级硬化胆管炎的患者才有类似的HLA DRB1 * 13的发生。 总之,HLA DRB1 * 13可能是一些白北美患者1型自身免疫性肝炎患者的遗传危险因素。

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