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首页> 外文期刊>Digestive Diseases and Sciences >Circulating microRNA-22-3p Predicts the Malignant Progression of Precancerous Gastric Lesions from Intestinal Metaplasia to Early Adenocarcinoma
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Circulating microRNA-22-3p Predicts the Malignant Progression of Precancerous Gastric Lesions from Intestinal Metaplasia to Early Adenocarcinoma

机译：循环MicroRNA-22-3P预测肠道细胞患者对早期腺癌的癌前胃病变的恶性进展

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Background Gastric cancer has a poor outcome and identifying useful biomarkers from peripheral blood or tissue could allow its early detection, or potentially precancerous changes, thus improving the curative rates. MicroRNAs (miRNAs) have been shown to offer great potential in cancer diagnosis and prediction. Aim Here, we investigated the role of plasma miRNAs in the natural course of gastric cancer, from intestinal metaplasia to early cancer. The findings were used to understand whether patients at a high risk of malignancy could be given appropriate interventions in the early disease process, such as using endoscopic submucosal dissection to treat gastric dysplasia or early gastric cancer. Methods Participants were divided into healthy control, intestinal metaplasia (IM), and dysplasia/early cancer (pT1a/b) groups. Microarray was used to select potential markers in tissue. Results Quantitative real-time polymerase chain reaction data showed circulating miRNA-22-3p had significantly different expression in patients with precancerous lesions or gastric adenocarcinoma. The areas under the curve of incomplete IM versus healthy control, low-grade/high-grade dysplasia, early gastric cancer, and GED were 0.8080, 0.8040, 0.8494, and 0.8095, respectively (all P values?
机译：背景技术胃癌具有较差的结果，并鉴定外周血或组织的有用生物标志物可以允许其早期检测，或潜在的癌前变化，从而提高疗效。已经显示MicroRNA（miRNA）在癌症诊断和预测中提供了巨大潜力。目的在这里，我们研究了血浆miRNA在胃癌自然过程中的作用，从肠道细胞到早期癌症。研究结果用于了解患者是否可以在早期疾病过程中适当干预患者，例如使用内窥镜粘膜粘膜缺陷治疗胃发育不良或早期胃癌。方法将参与者分为健康对照，肠道脑（IM）和发育不良/早期癌症（PT1A / B）组。微阵列用于选择组织中的潜在标志物。结果定量实时聚合酶链反应数据显示循环miRNA-22-3P对癌前病变或胃腺癌患者具有显着不同的表达。不完全IM与健康控制，低品位/高级发育不良，早期胃癌和GED的区域分别为0.8080,0.8040,0.8494和0.8095分别（所有P值？<0.05）。结论循环miRNA-22-3P可能是胃癌癌前发育困难和早期癌症检测的潜在生物标志物。

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