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首页> 外文期刊>Digestive Diseases and Sciences >Resolvin D1 Resolve Inflammation in Experimental Acute Pancreatitis by Restoring Autophagic Flux
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Resolvin D1 Resolve Inflammation in Experimental Acute Pancreatitis by Restoring Autophagic Flux

机译：Reqorvin D1通过恢复自噬助焊剂来解决实验急性胰腺炎中的炎症

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摘要

BackgroundAcute pancreatitis (AP) is a common acute gastrointestinal disorders. Increasing evidence indicated that autophagy is involved in the development of AP. Resolvin D1 is an endogenous pro-resolving lipid mediator, which can protect mice from cerulein-induced acute pancreatitis and facilitate autophagy in macrophage, but its mechanism remians unclear.AimsTo investigate the effect of resolvin D1 on autophagy in mouse models of cerulein-induced AP.MethodsC57BL/6 mice were randomly divided into control group, AP group and resolvin D1 group. The models of cerulein-induced AP were constructed by intraperitoneally cerulein. Resolvin D1 group was established by intraperitoneally resolvin D1 based on AP models, simultaneously, control group received normal saline. The severity of AP, the level of inflammatory cytokines, the number of autophagic vacuoles, and the expression of autophagy-related markers were evaluated among three groups.ResultsThe AP models were established successfully. Compared to control group, the number of autophagic vacuoles and expressions of autophagy-related markers including Beclin-1, p62 and LC3-II were increased in AP models, In contrast, the degree of inflammation and levels of inflammatory cytokines in AP models were reduced after resolvin D1 treatment. Moreover, resolvin D1 attenuated the number of autophagic vacuoles and expressions of autophagy-related markers.ConclusionsAutophagic flux is impaired in cerulein-induced AP. Resolvin D1 ameliorate the severity of mice with cerulein-induced acute pancreatitis, possible attributing to its reducing impaired autophagy and restoring autophagic flux.
机译：背景胰腺炎（AP）是一种常见的急性胃肠道障碍。越来越多的证据表明自噬涉及AP的发展。替换素D1是内源性促腐蚀脂质介质，可以保护来自Cerulein诱导的急性胰腺炎的小鼠，并促进巨噬细胞的自噬，但其机制不清楚.AIMSTO调查CERULEIN诱导的AP小鼠模型中reatvin d1对大鼠模型的疗效的影响.methodsc57bl / 6小鼠随机分为对照组，AP组和reatvin d1组。 Cerulein诱导的AP的模型由腹膜内的CERULEIN构建。通过基于AP模型的腹膜内易分辨率D1建立了reatvin D1组，同时，对照组接受了生理盐水。 AP的严重程度，炎症细胞因子，自噬液量的数量和自噬相关标记的表达在三组中进行了评估。在三组中评估了AP模型成功建立。与对照组相比，在AP模型中增加了自噬 - 液泡的数量和包括BECLIN-1，P62和LC3-II的自噬相关标记的表达，相比之下，AP模型中炎症性细胞因子的炎症程度和水平降低在reatvin d1治疗后。此外，Regarvin D1抑制了自噬相关标记的自噬液泡和表达的数量。Cerulein诱导的AP中的Conclusionsautophagic通量受损。 reatvin d1改善了Cerulein诱导的急性胰腺炎的小鼠的严重程度，可能归因于其降低损伤的自噬和恢复自噬助焊剂。

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  • 来源
    《Digestive Diseases and Sciences》 |2018年第12期|共8页
  • 作者

    Wang Bingbing; Hu Cui; Mei Yongyu; Bao Junjun; Ding Shaozhen; Liu Xiaochang; Mei Qiao; Xu Jianming;

  • 作者单位

    Anhui Med Univ Affiliated Hosp 1 Dept Gastroenterol Key Lab Digest Dis Anhui Prov 218 Jixi Rd;

    Anhui Med Univ Affiliated Hosp 1 Dept Gastroenterol Key Lab Digest Dis Anhui Prov 218 Jixi Rd;

    Anhui Med Univ Affiliated Hosp 1 Dept Gastroenterol Key Lab Digest Dis Anhui Prov 218 Jixi Rd;

    Anhui Med Univ Affiliated Hosp 1 Dept Gastroenterol Key Lab Digest Dis Anhui Prov 218 Jixi Rd;

    Anhui Med Univ Affiliated Hosp 1 Dept Gastroenterol Key Lab Digest Dis Anhui Prov 218 Jixi Rd;

    Anhui Med Univ Affiliated Hosp 1 Dept Gastroenterol Key Lab Digest Dis Anhui Prov 218 Jixi Rd;

    Anhui Med Univ Affiliated Hosp 1 Dept Gastroenterol Key Lab Digest Dis Anhui Prov 218 Jixi Rd;

    Anhui Med Univ Affiliated Hosp 1 Dept Gastroenterol Key Lab Digest Dis Anhui Prov 218 Jixi Rd;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 消化系及腹部疾病;
  • 关键词

    Resolvin D1; Autophagy; Acute pancreatitis; Inflammation;

    机译：reatvin d1;自噬;急性胰腺炎;炎症;

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