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首页> 外文期刊>AJR: American Journal of Roentgenology : Including Diagnostic Radiology, Radiation Oncology, Nuclear Medicine, Ultrasonography and Related Basic Sciences >Quantitative CT in chronic obstructive pulmonary disease: inspiratory and expiratory assessment.
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Quantitative CT in chronic obstructive pulmonary disease: inspiratory and expiratory assessment.

机译：慢性阻塞性肺疾病的定量CT：吸气和呼气评估。

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OBJECTIVE: The purpose of this study was to determine whether measurements of lung attenuation at inspiration and expiration obtained from 3D lung reconstructions reflect the severity of chronic obstructive pulmonary disease. SUBJECTS AND METHODS: Seventy-six patients with chronic obstructive pulmonary disease underwent MDCT with 3D postprocessing at full inspiration and full expiration. Inspiratory and expiratory mean lung density, percentage of lung volume with attenuation values less than -910 HU and -950 HU at inspiration and expiration, expiratory to inspiratory mean lung density ratio, and fifth and 15th percentiles of the lung attenuation distribution curve at inspiration and expiration were measured. RESULTS: When forced expiratory volume in the first second of expiration (FEV(1)) was 50% or greater than predicted value, mean lung density and lower attenuation volume measured from inspiratory MDCT scans correlated better with FEV(1) and ratio of FEV(1) to forced vital capacity (FVC) than did those from expiratory scans. When FEV(1) was less than 50% of predicted value, mean lung density and lower attenuation volume measured from expiratory MDCT scans correlated better with FEV(1) and ratio of residual volume to total lung capacity than did those values from inspiratory scans. Fifth percentile and 15th percentile of the lung attenuation distribution curve at both full inspiration and full expiration correlated well with FEV(1)/FVC and diffusing capacity of the lung for carbon monoxide as a percentage of predicted value but not well with FEV(1) as a percentage of predicted value regardless of FEV(1). CONCLUSION: Measurements of lung attenuation obtained at inspiration and visual score better reflect abnormal results of pulmonary function tests in patients with less severe chronic obstructive pulmonary disease than do measurements obtained at expiration. Measurements of lung attenuation obtained at expiration better reflect pulmonary function abnormalities in patients with severe chronic obstructive pulmonary disease.
机译：目的：本研究的目的是确定从3D肺重建获得的吸气和呼气时肺衰减的测量值是否反映了慢性阻塞性肺疾病的严重程度。研究对象和方法：76名慢性阻塞性肺疾病患者在完全吸气和完全过期的情况下接受了3D后处理的MDCT。吸气和呼气平均肺密度，吸气和呼气时衰减值小于-910 HU和-950 HU的肺容积百分比，呼气与吸气的平均肺密度比以及吸气和呼气时肺衰减分布曲线的第5个和第15个百分位数测量到期时间。结果：当呼气后第一秒（FEV（1））的呼气量大于预期值50％时，通过吸气MDCT扫描测得的平均肺密度和较低的衰减量与FEV（1）和FEV的比例更好相关（1）比呼气扫描的强制肺活量（FVC）强。当FEV（1）小于预测值的50％时，通过呼气MDCT扫描测得的平均肺密度和较低的衰减体积与FEV（1）和残气量与总肺活量之比的相关性要比吸气扫描更好。在完全吸气和完全呼气时，肺衰减分布曲线的第5个百分位和第15个百分位与FEV（1）/ FVC和肺对一氧化碳的扩散能力占预测值的百分比相关性很好，而与FEV（1）却不相关与FEV（1）无关的预测值百分比。结论：在轻度慢性阻塞性肺疾病患者中，通过吸气和视觉评分获得的肺衰减测量结果更好地反映了肺功能测试的异常结果，而在呼气时获得的测量结果却更好。呼气时测得的肺衰减量更好地反映了严重慢性阻塞性肺疾病患者的肺功能异常。

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