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首页> 外文期刊>Digestive Diseases and Sciences >A Nationwide Study of Inpatient Admissions, Mortality, and Costs for Patients with Cirrhosis from 2005 to 2015 in the USA
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A Nationwide Study of Inpatient Admissions, Mortality, and Costs for Patients with Cirrhosis from 2005 to 2015 in the USA

机译:2005年至2015年在美国肝硬化患者的住院入院,死亡率和成本的全国性研究

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Background and Aims Liver cirrhosis is a substantial health burden in the USA, but population-based data regarding the trend and medical expenditure are limited and outdated. We investigated the trends of inpatient admissions, costs, and inpatient mortality from 2005 to 2015 among cirrhotic patients. Methods A retrospective analysis was conducted using the National Inpatient Sample database. We adjusted the costs to 2015 US dollars using a 3% inflation rate. National estimates of admissions were determined using discharge weights. Results We identified 1,627,348 admissions in cirrhotic patients between 2005 and 2015. From 2005 to 2015, the number of weighted admissions in cirrhotic patients almost doubled (from 505,032 to 961,650) and the total annual hospitalization cost in this population increased three times (from 5.8 to 16.3 billion US dollars). Notably, admission rates varied by liver disease etiology, decreasing from 2005 to 2015 among patients with hepatitis C virus (HCV)-related cirrhosis while increasing (almost tripled) among patients with nonalcoholic fatty liver disease (NAFLD)-related cirrhosis. The annual inpatient mortality rate per 1000 admissions overall decreased from 63.8 to 58.2 between 2005 and 2015 except for NAFLD (27.2 to 35.8) (P < 0.001). Conclusions Rates and costs of admissions in cirrhotic patients have increased substantially between 2005 and 2015 in the USA, but varied by liver disease etiology, with decreasing rate for HCV-associated cirrhosis and for HBV-associated cirrhosis but increasing for NAFLD-associated cirrhosis. Inpatient mortality also increased by one-third for NAFLD, while it decreased for other diseases. Cost also varied by etiology and lower for HCV-associated cirrhosis.
机译:背景和AIMS肝硬化是美国的重大健康负担,但有关趋势和医疗支出的基于人口的数据是有限和过时的。我们调查了2005年至2015年在肝硬化患者中的住院入学,费用和住院死亡率的趋势。方法使用国家入住样本数据库进行回顾性分析。我们使用3%的通货膨胀率调整到2015美元的成本。国家批准的入学估计是使用放电重量确定的。结果我们在2005年至2015年期间鉴定了肝硬化患者的1,627,348名入学。从2005年到2015年,肝硬化患者的加权入学人数几乎翻了一番(从505,032到961,650),这个人口的年度住院费用增加三次(从5.8到163亿美元)。值得注意的是,肝病病因的入学率变化,乙型肝炎病毒(HCV)患者2005年至2015年的肝硬化患者,同时增加非酒精性脂肪肝病(NAFLD) - 相关性肝硬化的患者增加(几乎三倍)。 2005年至2015年期间,每1000人入院的年度死亡率每1000次入学总额从63.8至58.2分,除非NAFLD(27.2至35.8)(P <0.001)。结论肝硬化患者入学率和成本在美国2005年至2015年之间增加,而是因肝病病因而变化,肝病相关肝硬化和HBV相关肝硬化的率降低,但对NAFLD相关的肝硬化增加。适用于NAFLD的住院死亡率也增加了三分之一,而其他疾病也减少了三分之一。成本也因病因学等于HCV相关的肝硬化而变化。

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