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首页> 外文期刊>Digestive Diseases and Sciences >Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones
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Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones

机译：胆管结石肝切除患者随后胆管癌的发病率和预后

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Background and AimCholangiocarcinoma (CCA) often develops after the hepatic resection for hepatolithiasis as well as indwelling it. We studied the incidence and prognosis of subsequent CCA in patients with hepatolithiasis in South Korea.MethodsWe identified individuals with diagnosed CCA at the time of or after surgery, during 2002-2016, from the Korean National Health Insurance. The incidences and survival rates of subsequent CCA were analyzed and compared with concomitant CCA. The standardized incidence ratios (SIRs) of CCA in this cohort were evaluated in the standard Korean population. All data were stratified by the presence of intrahepatic or extrahepatic CCA, age and sex.ResultsOf the 7852 patients with hepatectomy for BDS, 433 (5.84%) had concomitant CCA. Over the 12-year follow-up, 107 of 7419 (1.98%) patients were diagnosed with subsequent CCA. Patients with hepatic resection for BDS revealed higher SIRs for subsequent CCA (12.89, 95% CI 10.96-15.15) in cases of both intrahepatic CCA (13.40, 10.55-17.02) and extrahepatic CCA (12.42, 9.98-15.46). The median survival time for subsequent CCA was 0.87years, while that for concomitant CCA was 2.79years. Having subsequent CCA (HR 2.71, 95% CI 2.17-3.40) and being male (HR 1.28, 1.05-1.57) were related to a shorter survival time. The CCA site and age at CCA diagnosis were not related to prognoses.ConclusionsSubsequent CCA developed in 2% of the patients with hepatic resection for benign BDS until 10years and was associated with poorer prognoses than concomitant CCA. Future studies focused on the long-term surveillance for CCA in such patients are needed.
机译：背景和Aimcholangiocarcinoma（CCA）经常在肝胆管术和肝脏切除后发生，以及留下它。我们研究了韩国肝胆管患者随后的CCA的发病率和预后。从韩国国民健康保险期间，在2002 - 2016年期间，在手术期间或之后鉴定了患有CCA的个体。分析随后的CCA的发生率和存活率，并与伴随的CCA进行了比较。在标准韩国人口中评估了该队列中CCA的标准化发病率（SIRS）。所有数据都是通过肝内或侵入性CCA，年龄和性别的存在分层分层。7852例肝切除术患者的BDS，433（5.84％）伴随着CCA。在12年的随访中，7419名（1.98％）患者患有随后的CCA。在肝内CCA（13.40,10.55-17.02）和脱毛CCA（12.42,9.98-15.46）的情况下，肝切除患者的肝切除患者揭示了随后的CCA（12.89,95％CI 10.96-15.96-15.96-15.15）的先生。后续CCA的中位存活时间为0.87年，而伴随的CCA为2.79年。随后的CCA（HR 2.71,95％CI 2.17-3.40）和雄性（HR 1.28,1.05-1.57）与较短的存活时间有关。 CCA诊断的CCA位点和年龄与预后无关。结合次序中的CCA在2％的肝切除患者中开发，良性BDS直到10年与较差的预期相关，而不是伴随的CCA。需要对这些患者的CCA长期监测的未来研究是必要的。

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