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首页> 外文期刊>Digestive Diseases and Sciences >Screening Women Aged 50-59 for CRC Using Fecal Occult Blood Test Produces Outcomes Similar to Men Undergoing Screening Colonoscopy
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Screening Women Aged 50-59 for CRC Using Fecal Occult Blood Test Produces Outcomes Similar to Men Undergoing Screening Colonoscopy

机译：使用FECAL隐匿性血液测试的CRC筛查50-59岁的女性产生类似于接受筛查结肠镜检查的男性的结果

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BackgroundAverage-risk women aged 50-59years have a lower incidence and mortality of colorectal cancer relative to age-matched men, calling into question the benefit of screening colonoscopy in this age group.AimsWe aimed to determine whether FOBT is an effective initial screening test in 50-59-year-old women.MethodsWe conducted a cross-sectional study using a computerized endoscopic report generator. We identified 320,906 individuals who had average-risk screening colonoscopy and 32,369 who had colonoscopy for positive FOBT. The primary outcome was the positive predictive value (PPV) of FOBT for large polyp(s) greater than 9mm, as a surrogate for advanced neoplasia.ResultsAmong patients aged 50-59years undergoing screening colonoscopy, men were more likely than women to have large polyps (6.3 vs 4.2%, p0.0001). Black women undergoing screening colonoscopy had higher rates of large polyps compared to non-Black women. The PPV in FOBT-positive men aged 50-54 (11.5%) and 55-59 (14.4%) was higher than in women aged 50-54 (6.1%) and 55-59 (5.4%). Despite this lower PPV, women aged 50-54 with a positive FOBT had a similar rate of large polyps as 50-54-year-old men undergoing screening colonoscopy (6.1 vs 6.3%, p=0.626).ConclusionsCRC screening with FOBT identifies 50-59-year-old men and women with a higher risk of large polyps. Since younger women have a lower risk of large polyps than men, screening with FOBT in 50-59-year-old non-Black women could be an effective screening strategy, with outcomes similar to the use of screening colonoscopy in 50-59-year-old men.
机译：Backgryoudaverage-Visual女性相对于年龄匹配的男性患有结肠直肠癌的发病率和死亡率较低，呼吁质疑在这个年龄组中筛查结肠镜检查的益处。旨在确定FOBT是一种有效的初始筛查测试吗？ 50-59岁女性。近期使用计算机内窥镜报告发生器进行了横断面研究。我们确定了320,906个患有平均风险的筛选结肠镜检查，32,369人患有阳性FOBT的结肠镜检查。主要结果是用于大于9mm的大息肉的阳性预测值（PPV），作为晚期肿瘤的替代品。50-59岁患者进行筛查的结肠镜检查，男性比女性更有可能有大息肉（6.3 Vs 4.2％，P <0.0001）。与非黑人女性相比，接受筛选结肠镜检查的黑人女性具有更高的大息肉率。 FOBT阳性男性50-54岁（11.5％）和55-59（14.4％）的PPV高于50-54岁（6.1％）和55-59（5.4％）。尽管PPV较低，50-54岁的女性患有阳性FOBT的大息肉率与50-54岁男性筛选的筛选结肠镜检查（6.1 VS 6.3％，P = 0.626）。ConclusionsCrc筛选用FOBT识别50 -59岁的男性和患有较高息肉风险的男性和女性。由于年龄较小的女性具有比男性的大息肉的风险较低，因此在50-59岁的非黑人女性中筛选FOBT可能是一个有效的筛查策略，结果类似于50-59岁的筛选结肠镜检查 - 男人。

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