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Clinician Guide to Microbiome Testing

机译：临床医生微生物磁石测试指南

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Recent recognition that the intestinal microbiome plays potential roles in the pathogenesis of multiple common diseases has led to a growing interest in personalized microbiome analysis among clinical investigators and patients. Permissibility of direct access testing has allowed the emergence of commercial companies offering microbiome analysis to patients seeking to gain a better understanding of their symptoms and disease conditions. In turn, physicians are often asked to help with interpretation of such tests or even requested by their patients to order them. Therefore, physicians need to have a basic understanding of the current state of microbiome science. This review examines how the perspective of microbial ecology, which is fundamental to understanding the microbiome, updates the classical version of the germ theory of disease. We provide the essential vocabulary of microbiome science and describe its current limitations. We look forward to the future when microbiome diagnostics may live up to its potential of becoming integral to clinical care that will become increasingly individualized, and microbiome analysis may become incorporated into that future paradigm. However, we caution patients and providers that the current microbiome tests, given the state of knowledge and technology, do not provide much value in clinical decisions. Considerable research remains to be carried out to make this objective a reality.
机译：最近识别：肠道微生物组在多种常见疾病的发病机制中发挥潜在作用导致临床研究人员和患者的个性化微生物组分析的兴趣日益增长。直接访问测试的允许性允许向寻求更好地了解其症状和疾病条件的患者提供微生物组分析的商业公司的出现。反过来，医生经常被要求帮助解释这些测试，或者甚至由患者要求订购它们。因此，医生需要对当前的微生物组科学状态有了基本的了解。本综述研究了微生物生态学的角度，这是理解微生物组的基础，更新疾病细菌理论的经典版本。我们提供微生物组科学的基本词汇，并描述其当前的限制。当微生物组诊断可能达到其对临床护理的可能性的潜力，我们期待着未来，这将越来越个性化，并且微生物组分析可能被纳入这种未来的范式。然而，我们小心患者和提供者认为，鉴于知识和技术的状态，在临床决策中不提供多大价值。相当大的研究仍有待开展，以使这一目标成为现实。

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