ANTIBODY PRODUCTION IN PLANTS [Review]

Smith MD

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ANTIBODY PRODUCTION IN PLANTS [Review]

机译：植物中的抗体生产[综述]

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摘要

Production of heterologous proteins in plants has become increasingly efficient due to recent advances in plant biotechnology. Heterologous proteins that have specifically attracted a great deal of attention are plant-produced monoclonal antibodies. A variety of applications for these so-called plantibodies have been explored since they were first expressed in tobacco seven years ago. Both full length antibodies and antibody fragments produced in transgenic plants offer many intriguing possibilities to plant molecular biologists and plant breeders. However, questions such as how cellular targeting influences the expression and accumulation of these proteins in plants still need to be answered before the technology can be used commercially, on a large-scale.

机译：由于植物生物技术的最新进展，植物中异源蛋白质的生产变得越来越有效。引起广泛关注的异源蛋白质是植物产生的单克隆抗体。自从七年前首次在烟草中表达这些植物体以来，已经探索了多种应用。转基因植物中产生的全长抗体和抗体片段都为植物分子生物学家和植物育种者提供了许多有趣的可能性。但是，诸如细胞靶向如何影响植物中这些蛋白质的表达和积累之类的问题仍需要回答，然后才能将该技术大规模地商业化使用。

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来源
《Biotechnology Advances: An International Review Journal》 |1996年第3期|共15页
作者
Smith MD;
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原文格式 PDF
正文语种 eng
中图分类生物工程学（生物技术）;
关键词
Heterologous protein; Plant biotechnology; Plantibodies; Immunotherapy; Transgenic tobacco; Engineered antibodies; Monoclonal-antibodies; Cell-walls; Expression; Immunoglobulins; Domains; Protein;

机译：异源蛋白;植物生物技术;植物体;免疫疗法;转基因烟草;工程抗体;单克隆抗体;细胞壁;表达;免疫球蛋白;结构域;蛋白质;

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专利

1. Medical molecular farming: production of antibodies, biopharmaceuticalsand edible vaccines in plants [Review] [J] . Daniell H, Streatfield SJ, Wycoff K Trends in Plant Science . 2001,第5期

机译：医学分子农业：在植物中生产抗体，生物制药和可食用疫苗[综述]
2. Production and glycosylation of plant-made pharmaceuticals: the antibodies as a challenge [Review] [J] . Gomord W, Sourrouille C, Fitchette AC, Plant Biotechnology Journal . 2004,第2期

机译：植物制作药物的生产和糖基化：抗体作为挑战[评论]
3. Production of antibodies and antibody fragments in plants [J] . Peeters K, De Wilde C, De Jaeger G, Vaccine . 2001,第17a19期

机译：在植物中产生抗体和抗体片段
4. “Production of Antibodies and Vaccines in Plants and Their Use for Global Health” [C] . International Symposium on the Biosafety of Genetically Modified Organisms; 20021010-16; Beijing(CN) . 2002

机译：“植物中抗体和疫苗的生产及其对全球健康的使用”
5. PRODUCTION AND USE OF MONOCLONAL ANTIBODIES FOR MOLECULAR CHARACTERIZATION, AFFINITY PURIFICATION, AND SEROLOGICAL DETECTION OF ECONOMICALLY SIGNIFICANT PLANT VIRUSES [D] . DIACO, ROBERT 1985

机译：单克隆抗体的生产和用途，用于分子鉴定，亲和纯化和经济检测重要植物病毒的血清学检测
6. ONeill S.D. Roberts J.A. Plant reproduction. Annual plant reviews vol. 6 [O] . A. J. Richards 2002

机译：ONeillS.D.RobertsJ.A.植物繁殖。年度工厂评论6
7. Obtenção de anticorpos policlonais contra proteínas presentes em plantas afetadas pela anomalia declínio dos citros Production of antibodies against proteins expressed in plants affected by citrus blight [O] . Sanzio Carvalho Lima Barrios, Juliana Erika Teixeira, Sebastião Márcio de Azevedo, 2006

机译：获得针对受异常柑橘降解影响的植物中存在的蛋白质的多克隆抗体产生针对受柑橘枯萎病影响的植物中表达的蛋白质的抗体的产生

ANTIBODY PRODUCTION IN PLANTS [Review]

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