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首页> 外文期刊>Domestic Animal Endocrinology >Intergenerational impact of maternal overnutrition and obesity throughout pregnancy in sheep on metabolic syndrome in grandsons and granddaughters
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Intergenerational impact of maternal overnutrition and obesity throughout pregnancy in sheep on metabolic syndrome in grandsons and granddaughters

机译：孕产妇过度和肥胖在孙子孙相和国代谢综合征的孕妇对孕妇的互补影响

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We previously reported that maternal overnutrition and obesity (MO) throughout pregnancy and lactation in sheep (MOFO) decreases term fetal pancreatic 5-cell numbers and increases perirenal adiposity producing hyperphagia, increased adiposity and insulin resistance in adult female offspring (MOF1) fed ad libitum. Pregnant female MOF1 exhibited increased blood glucose from mid to late gestation vs control Fl (CTRF1) though both groups ate only to NRC recommendations. MOF1 ewes delivered female offspring (F2) who like their MOF1 mothers exhibited increased abdominal adiposity and absent neonatal leptin surge. In the current work, we determined if adult MOF2 exhibited metabolic syndrome components when fed ad libitum. After weaning, MOF2 males (n = 5), MOF2 females (n = 6), CTRF2 males (n = 5), and CTRF2 females (n = 6) were fed to NRC requirements until 19 mo followed by 12-wk ad libitum feeding. Body weight and % fat increased (P 0.01) in all F2 during this feeding trial. MOF2 males were heavier (P 0.01) than CTRF2 males and females, and MOF2 females throughout the trial. By wk 8, baseline blood glucose concentrations increased (P 0.001) in MOF2 females, but not other groups, remaining elevated throughout the trial. Baseline insulin was similar through wk 6, increasing (P 0.05) at wk 8 in MOF2 females only. MOF2 female insulin returned to CTRF2 female levels during wk 10 and 12. The progressive increase of plasma glucose on wk 8 in association with increased insulin in MOF2 females but not other groups demonstrated a diet-induced increase (P 0.001) in MOF2 female insulin resistance. The subsequent decline in insulin during wk 10 and 12 despite elevated glucose in MOF2 females is consistent with a decrease in glucose stimulated pancreatic 5-cell function. These data indicate that ad libitum feeding exceeds the pancreatic secretory response predisposing MOF2 females to hyperglycemia. Furthermore, there was a sex difference where MOF2 males increased body mass and MOF2 females displayed insulin/glucose dysregulation. (C) 2017 Elsevier Inc. All rights reserved.
机译：我们之前报道，孕妇的过度和肥胖症（Mo）在绵羊（MOFO）中妊娠和哺乳期（MOFO）降低术语胎儿胰腺5细胞数，并增加了成年女性后代（MOF1）喂养过胆怯，增加了肥胖性肥胖性，增加了肥胖和胰岛素抵抗力。怀孕的雌性MOF1表现出从中期到后期妊娠的增加的血糖VS对照FL（CTRF1），尽管两个群体只吃了NRC建议。 MOF1母羊提供了女性后代（F2），他喜欢他们的MOF1母亲表现出增加的腹部肥胖和缺乏新生儿瘦素浪涌。在目前的工作中，我们确定成人MOF2是否在美联储自由时表现出代谢综合征组件。断奶后，MOF2雄性（n = 5），MOF2雌性（n = 6），CTRF2男性（n = 5），以及CTRF2女性（n = 6）被送到NRC要求，直到19 MO，然后是12 WK AD Libitum喂养。在该饲养试验期间，体重和％F2中的体重和％脂肪增加（p <0.01）。 MOF2男性比CTRF2雄性和女性更重（P＆ 0.01），以及整个试验中的MOF2女性。通过WK 8，基线血糖浓度在MOF2女性中增加（P <0.001），但不是其他群体，在整个试验过程中剩下升高。基线胰岛素通过WK 6类似，仅在MOF2女性中增加（P <0.05）。 MOF2雌性胰岛素在WK 10和12期间恢复到CTRF2雌性水平。与其他群体中的胰岛素增加，但不是其他组的胰岛素的血浆葡萄糖的逐渐增加表明，在MOF2雌性中表现出饮食诱导的增加（P <0.001）胰岛素抵抗。在WK 10和12期间随后的胰岛素下降尽管MOF2女性葡萄糖升高，这与葡萄糖刺激的胰腺5细胞功能的降低一致。这些数据表明，AD Libitum饲料超过胰腺分泌响应，将MOF2女性预测到高血糖症。此外，有一种性别差异，MOF2男性增加体重和MOF2雌性展示胰岛素/葡萄糖诱饵。 （c）2017年Elsevier Inc.保留所有权利。

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