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Microfluidic platforms for modeling biological barriers in the circulatory system

机译:用于在循环系统中建模生物屏障的微流体平台

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摘要

Microfluidic platforms have recently become popular as in vitro models because of their superiority in recapitulating microenvironments compared with conventional in vitro models. By providing various biochemical and biomechanical cues, healthy and diseased models at the organ level can be applied to disease progression and treatment studies. Microfluidic technologies are especially suitable for modeling biological barriers because the flow in the microchannels mimics the blood flow and body fluids at the interfaces of crucial organs, such as lung, intestine, liver, kidney, brain, and skin. These barriers have similar structures and can be studied with similar approaches for the testing of pharmaceutical compounds. Here, we review recent developments in microfluidic platforms for modeling biological barriers in the circulatory system.
机译:由于其与常规体外模型相比,微流体平台最近作为体外模型变得流行。 通过提供各种生物化学和生物力学提示,器官水平的健康和患病模型可以应用于疾病进展和治疗研究。 微流体技术特别适用于建模生物障碍,因为微通道中的流动在关键器官的界面中模仿血流和体液,例如肺,肠,肝,肾,脑和皮肤。 这些屏障具有相似的结构,可以用类似的方法进行研究,用于测试药物化合物。 在这里,我们审查了用于在循环系统中建模生物障碍的微流体平台的最新发展。

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  • 来源
    《Drug discovery today》 |2018年第4期|共15页
  • 作者单位

    Singapore Inst Mfg Technol 2 Fusionopolis Way 08-04 Singapore 138634 Singapore;

    Inst Mol &

    Cell Biol 61 Biopolis Dr Singapore 138673 Singapore;

    Singapore Inst Mfg Technol 2 Fusionopolis Way 08-04 Singapore 138634 Singapore;

    Inst Mol &

    Cell Biol 61 Biopolis Dr Singapore 138673 Singapore;

    Singapore Inst Mfg Technol 2 Fusionopolis Way 08-04 Singapore 138634 Singapore;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

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