Warsaw high-preferring (WHP) and Warsaw low-preferring (WLP) lines of rats selectively bred for high and low voluntary ethanol intake: preliminary phenotypic characterization.

Dyr W; Kostowski W

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Warsaw high-preferring (WHP) and Warsaw low-preferring (WLP) lines of rats selectively bred for high and low voluntary ethanol intake: preliminary phenotypic characterization.

机译：华沙高偏爱（WHP）和华沙低偏爱（WLP）品系的大鼠有选择地进行了自愿性酒精摄入量的高低选择：初步表型表征。

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The Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP) lines were bred from Wistar foundation stock to obtain lines of rats that differ in their preference for ethanol solutions. The WHP line has met several major criteria for an animal model of alcoholism. The WHP rats voluntarily drink excessive amounts of ethanol while the WLP rats consume negligible amounts of ethanol. The WHP rats attain physiologically active blood ethanol concentrations with chronic free-choice drinking. They also develop subtle but visible signs of physical dependence (the withdrawal signs). The patterns of ethanol consumption in WHP and WLP lines are stable in time and independent of the manner of access to ethanol solutions. Notably, when exposed to the increasing ethanol concentrations WHP rats gradually increased total ethanol intake whereas the WLP rats consumed invariably very low amounts of ethanol. Furthermore, the WHP rats show an increased responsiveness to the stimulatory effects of low dose of ethanol.

机译：从Wistar基础股票中选育出华沙高偏爱（WHP）和华沙低偏爱（WLP）品系，以获得在乙醇溶液方面偏好不同的大鼠品系。 WHP产品线已达到酒精中毒动物模型的几个主要标准。 WHP大鼠自愿喝过量的乙醇，而WLP大鼠消耗微不足道的乙醇。 WHP大鼠通过长期自由选择饮酒达到生理活性的血液乙醇浓度。他们还会出现细微但可见的身体依赖迹象（退缩迹象）。 WHP和WLP生产线中乙醇消耗的模式在时间上是稳定的，并且与获取乙醇溶液的方式无关。值得注意的是，当暴露于不断增加的乙醇浓度时，WHP大鼠逐渐增加了总乙醇摄入量，而WLP大鼠始终消耗非常少量的乙醇。此外，WHP大鼠显示出对低剂量乙醇刺激作用的增强反应性。

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《Alcohol》 |2008年第3期|共10页
作者
Dyr W; Kostowski W;
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正文语种 eng
中图分类预防医学、卫生学;内科学;
关键词
Alcohol Drinking; Alcoholism; Animals; Body Weight; Brain Chemistry; Breeding; Central Nervous System Depressants; Conditioning; Operant; Dopamine; Eating; Ethanol; Female; Male; Phenotype; Rats; Rats; Wistar; Sweetening Agents; *饮酒; 酒精中毒; 动物; 体重; 脑化学; 繁殖; 中枢神经系统抑制药; 条件反射; 操作式; 多巴胺; 进食; 表型; 大鼠; 大鼠; Wistar; 甜味剂;

机译：Alcohol Drinking;Alcoholism;Animals;Body Weight;Brain Chemistry;Breeding;Central Nervous System Depressants;Conditioning;Operant;Dopamine;Eating;Ethanol;Female;Male;Phenotype;Rats;Rats;Wistar;Sweetening Agents;*饮酒;酒精中毒;动物;体重;脑化学;繁殖;中枢神经系统抑制药;条件反射;操作式;多巴胺;进食;表型;大鼠;大鼠;Wistar;甜味剂;

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外文文献

1. Warsaw high-preferring (WHP) and Warsaw low-preferring (WLP) lines of rats selectively bred for high and low voluntary ethanol intake: preliminary phenotypic characterization. [J] . Dyr W, Kostowski W Alcohol . 2008,第3期

机译：华沙高偏爱（WHP）和华沙低偏爱（WLP）品系的大鼠有选择地进行了自愿性酒精摄入量的高低选择：初步表型表征。
2. Operant self-administration of ethanol in Warsaw High-Preferring (WHP) and Warsaw Low-Preferring (WLP) lines of rats. [J] . Rok-Bujko P, Dyr W, Kostowski W Pharmacological reports: PR . 2006,第6期

机译：在大鼠的华沙高偏好（WHP）和华沙低偏好（WLP）品系中进行乙醇的自我操作管理。
3. Operant self-administration of ethanol in Warsaw High-Preferring (WHP) and Warsaw Low-Preferring (WLP) lines of rats. [J] . Paulina Rok-Bujko, Wanda Dyr, Wojciech Kostowski Pharmacological reports: PR . 2006,第6期

机译：在大鼠的华沙高偏好（WHP）和华沙低偏好（WLP）品系中进行乙醇的自我操作管理。
4. Alterations in the seeking and self-administration of ethanol and anxiety-like behavior following exposure to yohimbine in rats selectively bred for high alcohol intake. [D] . Bertholomey, Megan Lee. 2011

机译：选择性摄入高酒精摄入的大鼠暴露于育亨宾后，对乙醇的寻求和自我管理的改变以及类似焦虑的行为。
5. Effect of repeated treatment with topiramate on voluntary alcohol intake and beta-endorphin plasma level in Warsaw alcohol high-preferring rats [O] . Jadwiga Zalewska-Kaszubska, Bartosz Bajer, Dorota Gorska, -1

机译：托吡酯反复治疗对华沙酒精高首选大鼠自愿饮酒和β-内啡肽血浆水平的影响
6. Acoustic Startle Responses and Prepulse Inhibition of Acoustic Startle Responses in Warsaw Alcohol High-Preferring (WHP) and Warsaw Alcohol Low-Preferring (WLP) Rats [O] . Albert Acewicz, Pawel Mierzejewski, Agata Jastrzebska, 2012

机译：声辐射响应和预析抑制华沙酒精高偏爱（WHP）和华沙低偏爱（WLP）大鼠

Warsaw high-preferring (WHP) and Warsaw low-preferring (WLP) lines of rats selectively bred for high and low voluntary ethanol intake: preliminary phenotypic characterization.

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