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Mimicking the ocular environment for the study of inflammatory posterior eye disorders

机译:模仿炎症后眼部疾病研究的眼部环境

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摘要

The common inflammatory posterior eye disorders, age-related degeneration and glaucoma often lead to irreversible vision loss. Current treatments do not target early stages or prevent disease progression. Consequently, the identification of biomarkers or early disease models that can accurately mimic the pathological processes involved is essential. Although none of the existing models can recapitulate all pathological aspects of these disorders, these models have revealed new therapeutic targets. Efforts to accurately phenotype eye disorders at various disease stages are warranted to generate a 'super' model that can replicate the microenvironment of the eye and associated pathological hallmarks effectively.
机译:常见的炎症后眼疾病,年龄相关的退化和青光眼通常导致不可逆的视力丧失。 目前的治疗不靶向早期或预防疾病进展。 因此,可以准确地模仿所涉及的病理过程的生物标志物或早期疾病模型是必不可少的。 虽然没有现有的模型可以重新承载这些障碍的所有病理方面,但这些模型揭示了新的治疗目标。 有助于在各种疾病阶段准确表型眼疾病的努力产生“超级”模型,可有效复制眼睛的微环境和相关的病理标志。

著录项

  • 来源
    《Drug discovery today》 |2017年第2期|共7页
  • 作者单位

    RMIT Univ Sch Hlth &

    Biomed Sci Discipline Lab Med Bundoora Vic 3083 Australia;

    RMIT Univ Sch Hlth &

    Biomed Sci Discipline Pharm Bundoora Vic 3083 Australia;

    RMIT Univ Sch Hlth &

    Biomed Sci Discipline Lab Med Bundoora Vic 3083 Australia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

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