Targeting Candida spp. to develop antifungal agents

Salci Tania P.; Negri Melyssa; Abadio Ana K. R.; Svidzinski Terezinha I. E.; Kioshima Erika S.

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Targeting Candida spp. to develop antifungal agents

机译：针对念珠菌SPP。开发抗真菌剂

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Invasive fungal infections are a complex challenge throughout the world because of their high incidence, mainly in critically ill patients, and high mortality rates. The antifungal agents currently available are limited; thus, there is a need for the rapid development of new drugs. In silico methods are a modern strategy to explore interactions between new compounds and specific fungal targets, but they depend on precise genetic information. Here, we discuss the main Candida spp. target genes, including information about null mutants, virulence, cytolocalization, co-regulatory genes, and compounds that are related to protein expression. These data will provide a basis for the future in silico development of antifungal drugs.

机译：由于其发病率高，主要是患者，侵袭性真菌感染是全世界的复杂挑战，主要是病患者，以及高死亡率。目前可用的抗真菌剂有限; 因此，需要快速发展新药。在Silico方法中是一种探讨新化合物和特定真菌目标之间相互作用的现代策略，但它们依赖于精确的遗传信息。在这里，我们讨论主要的念珠菌SPP。靶基因，包括有关含有缺失的突变体，毒力，细胞染色化，共调节基因和与蛋白质表达有关的化合物的信息。这些数据将为未来在抗真菌药物开发中提供基础。

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《Drug discovery today》 |2018年第4期|共13页
作者
Salci Tania P.; Negri Melyssa; Abadio Ana K. R.; Svidzinski Terezinha I. E.; Kioshima Erika S.;
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作者单位

Univ Estadual Maringa Av Colombo 5-790 Jd Univ BR-87020900 Maringa Parana Brazil;

Univ Estadual Maringa Av Colombo 5-790 Jd Univ BR-87020900 Maringa Parana Brazil;

Univ Estado Mato Grosso Campus Nova Xavantina BR-78690000 Nova Xavantina Mato Grosso Brazil;

Univ Estadual Maringa Av Colombo 5-790 Jd Univ BR-87020900 Maringa Parana Brazil;

Univ Estadual Maringa Av Colombo 5-790 Jd Univ BR-87020900 Maringa Parana Brazil;

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正文语种 eng
中图分类药学;
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1. Targeting Candida spp. to develop antifungal agents [J] . Salci Tania P., Negri Melyssa, Abadio Ana K. R., Drug discovery today . 2018,第4期

机译：针对念珠菌SPP。开发抗真菌剂
2. In vitro antifungal susceptibilities of isolates of Candida spp. and Aspergillus spp. from China to nine systemically active antifungal agents: data from the SENTRY antifungal surveillance program, 2010 through 2012 [J] . Pfaller Michael A., Castanheira Mariana, Messer Shawn A., Mycoses: Diagnosis, therapy and prophylaxis of fungal diseases . 2015,第4期

机译：念珠菌分离株的体外抗真菌药敏性。和曲霉属。从中国到九种系统活性抗真菌药：SENTRY抗真菌监测计划的数据，2010年至2012年
3. Potency of Anidulafungin Compared to Nine Other Antifungal Agents Tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: Results from the Global SENTRY Antimicrobial Surveillance Program (2008) [J] . Shawn A. Messer, Ronald N. Jones, Gary J. Moet, Journal of Clinical Microbiology . 2010,第8期

机译：与九种针对念珠菌，隐球菌和曲霉菌测试的其他抗真菌药相比，阿尼芬净的效力：全球SENTRY抗菌素监测计划的结果（2008年）
4. Effect of antifungal agents on non-Candida albicans Candida species enzymatic activity [C] . M. Negri, T. Loren?o, S. Silva, International Conference on Antimicrobial Research . 2011

机译：抗真菌剂对非念珠菌白醛念珠菌物种酶活性的影响
5. Developing Novel Anti-cancer Agents Targeting Na+/K +-ATPase [D] . Alharbi, Yousef. 2019

机译：开发针对Na + / K + -ATPase的新型抗癌药
6. Potency of Anidulafungin Compared to Nine Other Antifungal Agents Tested against Candida spp. Cryptococcus spp. and Aspergillus spp.: Results from the Global SENTRY Antimicrobial Surveillance Program (2008) [O] . Shawn A. Messer, Ronald N. Jones, Gary J. Moet, 2010

机译：与九种其他抗念珠菌隐球菌和曲霉菌测试的抗真菌药相比阿尼芬净的效力：全球SENTRY抗菌素监测计划的结果（2008年）
7. Potency of Anidulafungin Compared to Nine Other Antifungal Agents Tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: Results from the Global SENTRY Antimicrobial Surveillance Program (2008) ▿ [O] . Messer, Shawn A., Jones, Ronald N., Moet, Gary J., 2010

机译：与九种其他抗念珠菌，隐球菌和曲霉菌测试的抗真菌药相比，阿尼芬净的效力：全球SENTRY抗菌素监测计划（2008）的结果▿

Targeting Candida spp. to develop antifungal agents

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