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首页> 外文期刊>Drug discovery today. Disease models >Modelling in miniature: Using Drosophila melanogaster to study human neurodegeneration
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Modelling in miniature: Using Drosophila melanogaster to study human neurodegeneration

机译：微型建模：使用果蝇马拉替洛克斯研究人类神经变性

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Despite great advances in clinical diagnostics, genetics and molecular biology, neurodegenerative diseases like Parkinson's disease (PD), Alzheimer's disease (AD) and Huntington's disease (HD) still pose great challenges, both in terms of understanding their pathophysiology as well as their treatment. Organisms able to adequately model the intricacies of the disease mechanism and respose to potential treatment, whilst not compromising on ease of handling, studying and manipulating in order to study them, represent the holy grail of translational biology and medicine. Here, we review the suitability of the fruit fly, Drosophila melanogaster, as a model organism in the field of neurodegeneration. We briefly summarize the history of scientific research concerning this organism, review the molecular, genetic and pharmacological toolbox available and we discuss the ways this toolbox has been applied to research in neurodegeneration. Finally, by reviewing some findings in the fruit fly which were subsequently translated to and validated in other organisms on their way to the clinic, the power and robustness of Drosophila melanogaster is highlighted.
机译：尽管临床诊断，遗传和分子生​​物学的进步，但帕金森病（Pd）等神经变性疾病，阿尔茨海默病（AD）和亨廷顿的疾病（HD）仍然存在巨大的挑战，无论是理解他们的病理生理学还是治疗。能够充分模仿疾病机制的复杂性并呼吸潜在治疗的生物，同时在易于处理，研究和操纵以研究它们，代表翻译生物学和药物的圣杯。在这里，我们审查了果蝇的适用性，果蝇果蝇，作为神经变性领域的模型生物体。我们简要概述了关于这种生物的科学研究史，审查了可用的分子，遗传和药理学工具箱，我们讨论了该工具箱已应用于神经变性研究的方式。最后，通过审查果蝇中的一些发现，随后在其前往诊所的其他生物中转化为并验证的结果，突出了果蝇的力量和鲁棒性。

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