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首页> 外文期刊>AJRI: American Journal of Reproductive Immunology >Interleukin-6 and soluble interleukin-6 receptor serum levels in recurrent spontaneous abortion women immunized with paternal white cells.
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Interleukin-6 and soluble interleukin-6 receptor serum levels in recurrent spontaneous abortion women immunized with paternal white cells.

机译：用父本白细胞免疫的反复自然流产妇女的白细胞介素6和可溶性白细胞介素6受体血清水平。

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PROBLEM: Recurrent spontaneous abortion (RSA) could be interpreted as the cause for the incapacity of the mother to recognize paternal antigens to produce the desired protective response. The practise of alloimmunization was introduced in an attempt to induce in the mother the production of an alloimmune response; some authors proposed an association between cytokines and RSA. The production of IL6 and its soluble receptor (sIL6R) before and after lymphocyte immunotherapy was evaluated in sera of 33 patients suffering from two or more RSA, and in sera of 47 women with normal pregnancy. METHOD OF STUDY: The immunization of RSA patients was achieved by injection of four doses of 10(5) mononuclear cells (MNC) from the husband, at weekly intervals, before pregnancy. The IL6 and sIL6R levels were measured using sandwich ELISAs and the results evaluated by Tukey-Kramer multiple comparison-tests. RESULTS: Our data show no significant differences between IL6 and sIL6R serum levels of normal pregnant women and RSA pregnant women with white-cell immunization before pregnancy. In contrast, the sera of pregnant RSA patients without allogeneic therapy show higher values. We also found significant differences between IL6 levels in non-pregnant RSA women with and without immunotherapy. CONCLUSION: These results show that the alloimmunization with paternal white cells leads the serum IL6 and sIL6R-levels to the values observed in the course of normal pregnancy, suggesting a role for IL6 and sIL6R in the modulation of the immune response's quality.
机译：问题：反复自然流产（RSA）可能被解释为母亲无能力识别父本抗原以产生所需保护性应答的原因。引入同种免疫的做法是为了在母亲中诱导同种免疫反应的产生。一些作者提出了细胞因子与RSA之间的关联。在33名患有两种或多种RSA的患者的血清中，以及在47名正常妊娠妇女的血清中，评估了淋巴细胞免疫治疗前后IL6及其可溶性受体（sIL6R）的产生。研究方法：通过在怀孕前每周从丈夫注射四剂10（5）单核细胞（MNC），实现RSA患者的免疫。使用夹心ELISA法测量IL6和sIL6R水平，并通过Tukey-Kramer多重比较测试评估结果。结果：我们的数据显示正常孕妇和RSA孕妇在怀孕前进行白细胞免疫的IL6和sIL6R血清水平之间无显着差异。相反，未进行同种异体治疗的怀孕RSA患者的血清显示较高的值。我们还发现在有和没有免疫疗法的非怀孕RSA妇女中，IL6水平之间存在显着差异。结论：这些结果表明，用父本白细胞进行同种异体免疫可使血清IL6和sIL6R水平达到正常怀孕过程中观察到的值，表明IL6和sIL6R在调节免疫应答质量中起作用。

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