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首页> 外文期刊>DNA and Cell Biology >Immunostimulant adjuvant patch enhances humoral and cellular immune responses to DNA immunization
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Immunostimulant adjuvant patch enhances humoral and cellular immune responses to DNA immunization

机译：免疫刺激剂辅助贴剂增强了对DNA免疫的体液和细胞免疫应答

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The focus of this report is on the development of an improved DNA immunization protocol, which takes advantage of the strengths of DNA immunization, as well as those associated with adjuvant delivered by transcutaneous immunostimulatory (IS) patches. Because transcutaneous delivery of adjuvants to the skin at the vaccination site has been shown to amplify the immune response to protein antigens, we hypothesized that the same IS patch when placed on the skin at the site of DNA injection could further enhance the immune response to a DNA influenza vaccine. We have combined an influenza DNA vaccine, hemagglutinin fused with three copies of complement C3d, to enhance uptake and antigen presentation, with an IS patch containing heat-labile enterotoxin from Escherichia coli. Coadministration of a potent adjuvant in IS patches placed on the skin at the site of DNA vaccination dramatically amplifies anti-influenza antibody immune response. Supplementing DNA vaccines with IS patches may be a particularly valuable strategy because DNA vaccines can be rapidly modified in response to mutations in pathogens, and individuals with compromised immune systems such as transplant patients and the elderly will benefit from the enhanced antibody response induced by the IS patches.
机译：本报告的重点是开发改进的DNA免疫协议，该方案利用DNA免疫的优点，以及与经皮免疫刺激（IS）贴片递送的佐剂相关的那些。因为已经显示出在疫苗接种位点对皮肤的皮肤过度递送的辅助递送对蛋白质抗原的免疫应答，所以我们假设相同的是贴片当置于DNA注射部位的皮肤上，可以进一步增强免疫应答DNA流感疫苗。我们组合了一种流感DNA疫苗，血凝素与三个补体C3D拷贝融合，增强摄取和抗原呈递，其中含有来自大肠杆菌的热稳定肠毒素。有效的辅助辅助辅助辅助的贴片是DNA疫苗接种位点上的皮肤上的斑块显着放大抗流感抗体免疫应答。补充DNA疫苗的斑块可能是特别有价值的策略，因为可以在响应病原体中的突变迅速修饰DNA疫苗，并且具有受损免疫系统（如移植患者和老年人）的个体将受益于所诱导的增强抗体反应补丁。

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