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Advances on Cell Autophagy and Its Potential Regulatory Factors in Renal Ischemia-Reperfusion Injury

机译：肾缺血再灌注损伤细胞自噬及其潜在监管因素的研究进展

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摘要

Ischemia-reperfusion injury is a major reason for acute kidney injury and various kidney diseases. Autophagy plays an important role during renal ischemia-reperfusion injury (RIRI), but it remains controversial whether autophagy contributes to cell survival or ischemia-reperfusion-induced cell death. In the review, we summarized the function of autophagy in the progression of acute ischemic kidney injury, as well as its related molecular mechanisms. While analyzing the opposite roles of autophagy in RIRI, it was concluded that the protective or detrimental function of autophagy was depending on the timing and amount of the activation of cell autophagy. We also summarized the regulatory agents, including active compounds, proteins, or microRNAs (miRNAs), which regulated the cell autophagy during renal acute ischemic kidney injury process. This explained why the opposite conclusion occurred when cell autophagy was studied in the RIRI models from different researchers. Therefore, the article provided a hypothesis to control cell autophagy at the appropriate timing and intensity so as to alleviate renal injury and sustain cell survival of the renal cell.
机译：缺血再灌注损伤是急性肾损伤和各种肾病的主要原因。自噬在肾缺血再灌注损伤（RIRI）中发挥着重要作用，但仍然存在争议的自噬否则是否有助于细胞存活或缺血再灌注诱导的细胞死亡。在审查中，我们总结了自噬在急性缺血性肾损伤进展中的功能，以及其相关分子机制。在分析RIRI中的自噬作用的同时，得出结论是自噬的保护或有害功能取决于细胞自噬激活的时序和量。我们还总结了调节剂，包括活性化合物，蛋白质或微小RNA（miRNA），其在肾急性缺血性肾损伤过程中调节细胞自噬。这解释了为什么当在不同研究人员的里拉模型中研究了细胞自噬时，为什么发生相反的结论。因此，本文提供了一种假设，用于在适当的时序和强度下控制细胞自噬，以减轻肾损伤和维持肾细胞的细胞存活。

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  • 来源
    《DNA and Cell Biology》 |2019年第9期|共10页
  • 作者

    Hou Jing; Rao Mingyue; Zheng Wenlu; Fan Junming; Law Betty Yuen Kwan;

  • 作者单位

    Macau Univ Sci &

    Technol Fac Chinese Med Ave Wai Long Taipa 999078 Macao Peoples R China;

    Macau Univ Sci &

    Technol Fac Chinese Med Ave Wai Long Taipa 999078 Macao Peoples R China;

    Macau Univ Sci &

    Technol Fac Chinese Med Ave Wai Long Taipa 999078 Macao Peoples R China;

    Chengdu Med Coll 783 Xindu Ave Chengdu 610500 Sichuan Peoples R China;

    Macau Univ Sci &

    Technol Fac Chinese Med Ave Wai Long Taipa 999078 Macao Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞遗传学;
  • 关键词

    IRI; kidney; autophagy; regulation;

    机译：IRI;肾脏;自噬;规定;

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